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Listar por autor "Fernández-Llebrez, Pedro"
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes, Manuel; Pérez-Martín, Margarita; [et al.] (2014-07-14)Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Análisis de la neurogénesis cortical en el desarrollo cerebral de ratones carentes del receptor de ácido lisofosfatídico LPA1
Fernández-Llebrez, Pedro (Servicio de Publicaciones y Divulgación Científica, 2016)El ácido lisofosfatídico (LPA) es un fosfolípido sencillo con propiedades de señalización extracelular mediadas por receptores de membrana específicos acoplados a proteínas G. Actualmente se conocen hasta 6 tipos de ... -
Análisis de la reacción inflamatoria y los procesos degenerativos provocados por la inyección intracerebroventricular de neuraminidasa en rata
Granados-Durán, Pablo (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Las infecciones víricas y bacterianas del sistema nervioso central (SNC) y la neuroinflamación han sido relacionadas en los últimos años con en el desarrollo de ciertas enfermedades neurodegenerativas, tales como la ... -
Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernandez-Arjona, Mar; Grondona, Jesus; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
Desarrollo del epéndimo y subepéndimo en modelos animales en condiciones normales y en la hidrocefalia congénita
Rodriguez-Perez, Luis Manuel (Servicio de Publicaciones y Divulgacion Cientifica, 2016)La presente Tesis Doctoral se ha diseñado para responder a las siguientes hipótesis: 1.- El programa de diferenciación de la zona ventricular que se afecta en el ratón hyh pone de manifiesto que la población celular que ... -
FGF2, but not EGF, Induces multiciliated ependymal cells to dedifferentiate and adopt radial glial features in vitro
Grondona, Jesús M; Granados-Durán, Pablo; Navarro Dueñas, Isabel; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2014-07-21)Multiciliated ependymal cells form an epithelium lining most of the ventricular cavities of vertebrates brain. Although considered postmitotic and completely differentiated, ependymal cells maintain some phenotypic ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona JM; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Morphological traits of surveillant/activated microglia during an experimentally induced acute neuroinflammatory process
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesus; Fernández-Llebrez, Pedro (2016-07-12)Several studies show that morphological changes of microglia over the course of inflammation are tightly coupled to function. However the progressive transformation into activated microglia is poorly characterized. AIMS: ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernandez-Arjona, Mar; López-Ávalos, María Dolores; Grondona, Jesus; Carrillo-Pinzon, Cristobal; Fernández-Llebrez, Pedro (2017-10-04)Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Grondona, Jesús M; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Grondona, Jesús M; [et al.] (2015-05-27)Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...