Listar por autor "Estivill-Torrús, Guillermo"
Mostrando ítems 1-20 de 24
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Análisis de la neurogénesis cortical en el desarrollo cerebral de ratones carentes del receptor de ácido lisofosfatídico LPA1
Fernández-Llebrez, Pedro (Servicio de Publicaciones y Divulgación Científica, 2016)
El ácido lisofosfatídico (LPA) es un fosfolípido sencillo con propiedades de señalización extracelular mediadas por receptores de membrana específicos acoplados a proteínas G. Actualmente se conocen hasta 6 tipos de ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez, Juan; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2016-07-13)
Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, Maria del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Carames-Tejedor, Jose Maria; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesus; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; Pedraza-Benítez, Maria del Carmen; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (2015-09-18)
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gómez, José Ángel; Martinez-Montañez, Elisa; Pavia-Molina, Jose; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo; García-Fernández, Maria Inmaculada[et al.] (2013-10-02)
El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Effects of Nanocrystalline Glass-like Carbon thin films on the SN4741 Dopaminergic cell Parkinson model
Rodriguez-Losada; Romero, Pablo; Estivill-Torrús, Guillermo; Guzmán de Villoria, Roberto; Aguirre-Gómez, José Ángel (2017-10-04)
The interest in carbon nanomaterials has grown within the last decade in view of a wide variety of applications. In this work we test the biocompatibility of a particular nanometer-thin nanocrystalline glass-like carbon ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-06-28)
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Estrés y depresión. El papel del receptor LPA1 para el ácido lisofosfatídico
(Uma Editorial, 2019-10)La depresión es un trastorno muy prevalente, cuya incidencia está en aumento y con consecuencias devastadoras en la salud de las personas. A pesar de ello, las bases neurobiológicas no son del todo conocidas. Esto podría ... -
Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies
Aguilar-Castillo, María José; Cabezudo-García, Pablo; Ciano-Petersen, Nicolas Lundahl; García-Martin, Guillermina; Marín-Gracia, Marta; Estivill-Torrús, Guillermo; Serrano-Castro, Pedro Jesus[et al.] (IOAP-MPDI, 2022-03-19)
Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, A.L.; García-Fernández, Maria Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2019)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
More adult-born dentate gyrus neurons to weaken cocaine-related retrograde memories: an in vivo strategy employing exogenous lysophosphatidic acid
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-28)
The post-training enhancement of adult hippocampal neurogenesis (AHN) has been receiving growing interest as a potential method to manipulate retrograde memories. Recent hypothesis suggest that the addition of adult-born ... -
Nuevas aproximaciones terapéuticas mediante las vías de señalización del ácido lisofosfatídico: regulación farmacológica y trasplante neuronal
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Los lisofosfolípidos son derivados de fosfolípidos de la membrana celular y uno de los más estudiados es el ácido lisofosfatídico (LPA), considerado como un importante regulador de diversas funciones biológicas. Hasta la ... -
Papel del receptor del ácido lisofosfatídico LPA1 en la neurogénesis hipocampal adulta y la memoria espacial en situaciones de estrés crónico
Castilla-Ortega, María Estela (Universidad de Málaga, Servicio de Publicaciones, 2011)
Este estudio muestra que los ratones carentes del receptor del ácido lisofosfatídico LPA1 (LPA1-nulos) presentan déficit de memoria espacial. Además, el efecto del estrés crónico sobre la neurogénesis hipocampal adulta y ... -
Reduction of adult hippocampal neurogenesis modifies brain functional connectivity and enhances cocaine-seeking in mice
Castilla-Ortega, María Estela; Ladrón de Guevara-Miranda, David; Blanco-Calvo, Eduardo; Serrano, Antonia; Pedraz, María; Estivill-Torrús, Guillermo; Pavón, Francisco; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier[et al.] (2015-09-16)
Recently, adult hippocampal neurogenesis has been proposed as a putative neuroplastic mechanism involved in those behavioural processes. In this work, we studied the effect of the inhibition of adult hippocampal neurogenesis ... -
Role of the LPA1 receptor in mood and emotional regulation
Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2015-09-16)
Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; García-Fernández, Maria Inmaculada; Chun, Jerold; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-17)
Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ...