Listar por autor "Alonso-Sánchez, María del Carmen"
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Actividad antagonista de aislados del Virus de la Septicemia Hemorrágica Viral (VHSV) frente al sistema del interferón tipo I de lenguado senegalés
Gémez-Mata, Juan; Álvarez-Torres, Daniel; García-Rosado, Esther
; Alonso-Sánchez, María del Carmen; Béjar-Alvarado, Julia (2017-10-11)
Senegalese sole (Solea senegalensis) is susceptible to marine Viral Haemorrhagic Septicaemia Virus (VHSV) isolates, but it is not affected by freshwater VHSV isolates. In addition, the sole type I interferon (IFN I) response ... -
Actividad inmunomoduladora y antiviral del Propil Propano Tiosulfinato, un compuesto derivado de la cebolla, frente a betanodavirus
Moreno, Patricia; Baños-Arjona, Alberto; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Béjar-Alvarado, Julia (2022-11)
Los compuestos organosulfurados de las especies del género Allium, como el PropilPropano Tiosulfinato (PTS), se utilizan como aditivos funcionales en alimentación animal por sus propiedades antimicrobianas. Sin embargo, ... -
Antiviral activity of European sea bass ISG15 against betanodavirus infections
Moreno, Patricia; García-Rosado, Esther; Borrego-García, Juan José; Alonso-Sánchez, María del Carmen (2017)
To study the role of the sea bass ISG15 protein against betanodavirus infections, an in vivo transcription analysis has been performed after RGNNV infection and poly I:C inoculation, and the sea bass ISG15 activity has ... -
Antiviral activity of mx proteins from gilthead seabream (sparus aurata) against lymphocystis disease virus (LCDV).
Fernández-Trujillo, M. Alejandra; García-Rosado, Esther; Alonso-Sánchez, María del Carmen; Borrego-García, Juan José; Álvarez-Herrero, María del Carmen; Béjar-Alvarado, Julia[et al.] (ELSEVIER, 2013)
Gilthead seabream (Sparus aurata), one of the most important fish species in the Mediterranean Aquaculture displays a high natural resistance to viral diseases. Until now, the main viral disease affecting gilthead seabream ... -
Anti‑nervous necrosis virus activity of the growth hormone releasing peptide‑6, GHRP‑6
Álvarez-Torres, Daniel; Martínez, Rebeca; Moreno, Patricia; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Porras Estrada, Mario; Béjar-Alvarado, Julia[et al.] (Springer Nature, 2025-04-30)
Growth hormone-releasing peptide 6 (GHRP-6), is a six-amino acid synthetic peptide that acts as a ghrelin analog and has shown growth-promoting and immunomodulatory activities in several fish species. This study evaluates ... -
Betanodavirus Quantification and IFN I-Antagonism Detection Using Luciferase Reporter Systems Based on Fish mx Promoters
Álvarez-Torres, Daniel; Moreno, Patricia; García-Rosado, Esther; Alonso-Sánchez, María del Carmen; Béjar-Alvarado, Julia (Wiley, 2025-06-12)
Mx genes display strong and quick induction in response to viral infections, which varies according to the viral virulence; furthermore, mx transcription is blocked by several viruses as part of their immune evasion ... -
Betanodavirus virulence to European sea bass (Dicentrarchus labrax): a new insight into virus-host interaction
(UMA Editorial, 2018-12-21)Viral diseases are the result of the pathogen virulence, the host immunity mechanisms, and the interaction between those components, which constitutes the so called host-pathogen interaction. This PhD Thesis is a comprehensive ... -
Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass
Moreno García, Patricia; Souto-Pereira, Sandra; Leiva Rebollo, Rocío; Bandín Matos, Isabel; Alonso-Sánchez, María del Carmen (Springer Nature, 2019-10-19)
European sea bass (Dicentrarchus labrax) is severely afected by nervous necrosis disease, caused by nervous necrosis virus (NNV). Two out of the four genotypes of this virus (red-spotted grouper nervous necrosis virus, ... -
Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass.
Moreno, Patricia; Souto, Sandra; Leiva-Rebollo, Rocío; Borrego-García, Juan José; Bandin, Isabel; Alonso-Sánchez, María del Carmen[et al.] (Nature Pubishing Group, 2019-10-01)
The role of the capsid protein (Cp) amino acids 247 and 270 in the virulence of a RGNNV isolate to sea bass (Dicentrarchus labrax) has been evaluated by the generation of recombinant RGNNV viruses harbouring SJNNV-type ... -
Characterization of Senegalese sole (Solea senegalensis) Mx promoter
Carballo Perez, Carlos; Alonso-Sánchez, María del Carmen; Collet, Bertrand; Béjar-Alvarado, Julia; Álvarez-Torres, Daniel; García-Rosado, Esther[et al.] (Elsevier, 2013)
Type I interferon (IFN) represents a first component of the innate immune response against viral infections, promoting an antiviral state in cells. Mx proteins are the best studied IFN-inducible genes (ISGs) in fish. The ... -
Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells
Moreno García, Patricia; Leiva Rebollo, Rocío; García Rosado, Esther; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen (Elsevier, 2022-08-18)
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a previous study, we developed ... -
Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells
Moreno-García, Patricia; Leiva-Rebollo, Rocío; García-Rosado, Esther; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen (Elsevier, 2022-08-23)
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a previous study, we developed ... -
Development of in vitro systems to study IFN signalling in gilthead seabream (Sparus aurata)
González-Mariscal, J.A.; Fernández-Trujillo, M. Alejandra; Méndez, T.; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Álvarez-Herrero, María del Carmen; Béjar-Alvarado, Julia[et al.] (2014-12-11)
Type I interferon (IFN I) triggers specific signalling pathways leading to the activation of the innate immune defence of vertebrates against viral infections. In contrats, type II IFN (IFN II) is generally accepted to be ... -
Differences in the viral induction of the senegalese sole Mx protein in RTG-2 and CHSE-214 cells
Álvarez-Torres, Daniel; Podadera, Ana Maria; García-Rosado, Esther; Collet, Bertrand; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen[et al.] (EAFP, 2013)
Transfected RTG-2 cells infected with VHSV showed significant induction of the luciferase reporter gene, compared to the control non-infected cells, at 24, 48 and 72 h post infection (p.i.). The maximum expression was ... -
Differential antiviral activity of European sea bass interferon-stimulated 15 protein (ISG15) against RGNNV and SJNNV betanodaviruses.
Moreno, Patricia; Álvarez-Torres, Daniel; García-Rosado, Esther; Borrego-García, Juan José; Alonso-Sánchez, María del Carmen (ScienceDirect, 2018-09-07)
ISG15 is an antiviral protein acting intracellularly, by conjugation to viral or cellular proteins, or extracellularly, as cytokine. In this work, an in vitro system, consisting of E-11 cells over-expressing European sea ... -
Differential antiviral activity of Porphyridium cruentum polysaccharides against VHSV and NNV infections
Parra-Riofrio, Geovanna; Moreno-García, Patricia; Abdala-Díaz, Roberto Teófilo; García-Rosado, Esther; Uribe-Tapia, Eduardo; Alonso-Sánchez, María del Carmen; Béjar-Alvarado, Julia[et al.] (2021-09)
The use of functional food can be an interesting approach to prevent viral diseases in aquaculture facilities. An increasing number of studies have suggested that marine microorganisms can be a relevant source of substances ... -
Differential immunogene expression profile of European sea bass (Dicentrarchus labrax, L.) in response to highly and low virulent NN
Moreno, Patricia; Gémez-Mata, Juan; García-Rosado, Esther; Béjar-Alvarado, Julia; Labella Vera, Alejandro Manuel; Souto, Sandra; Alonso-Sánchez, María del Carmen[et al.] (Elsevier, 2020)
European sea bass is highly susceptible to the nervous necrosis virus, RGNNV genotype, whereas natural outbreaks caused by the SJNNV genotype have not been recorded. The onset and severity of an infectious disease depend ... -
Differential induction of the gilthead seabream Mx1, Mx2 and Mx3 promoters by IPNV and VHSV
González-Mariscal, J.A.; Fernández-Trujillo, M. Alejandra; Méndez, T.; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Álvarez-Herrero, María del Carmen; Béjar-Alvarado, Julia[et al.] (2014-10-07)
Type I interferon (IFN I) system triggers specific signalling pathways leading to the activation of the innate immune defence of vertebrates against viral infections. The complex expression regulation of Interferon Stimulated ... -
Estimulación del sistema mediado por interferón tipo I de lenguado senegalés (Solea senegalensis) en respuesta a infecciones por nodavirus
Podadera, AM; Álvarez-Torres, Daniel; Souto, S; Bandín Matos, Isabel; Alonso-Sánchez, María del Carmen (2014-09-25)
El lenguado senegalés es susceptible a la infección por el Virus de la Necrosis Nerviosa Viral (VNNV). Los betanodavirus se clasifican en cuatro genotipos, siendo los genotiposSJNNV, RGNNV y virus recombinantes RGNNV-SJNNV ... -
Estudio in vitro de la actividad antagonista de aislados del virus de la septicemia hemorrágica viral (VHSV) de distinto origen sobre el sistema del IFN tipo I
Gémez-Mata, Juan; Álvarez-Torres, Daniel; Alonso-Sánchez, María del Carmen; García-Rosado, Esther; Béjar-Alvarado, Julia (2018-11-09)
El lenguado senegalés (Solea senegalensis) es susceptible a aislados marinos del virus de la septicemia hemorrágica viral (VHSV); sin embargo, los VHSV patógenos para especies de agua dulce no son virulentos para especies ...