Listar por autor "Ortega-Prieto, Ana María"
Mostrando ítems 1-16 de 16
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3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.
(Springer-Nature, 2018-02-14)With more than 240 million people infected, hepatitis B virus (HBV) is a major health concern. The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose ... -
Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
(Elsevier, 2023)High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key ... -
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2.
(PLOS, 2022)The COVID-19 pandemic has accelerated the need to identify new antiviral therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds ... -
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
(Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ... -
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis
Ortega-Prieto, Ana María; Sheldon, Julie; Grande-Pérez, Ana
; Tejero, Hector; Gregori, Josep; Quer, Josep; Esteban, Juan I.; Domingo, Esteban; Perales, Celia[et al.] (PLOS One, 2013-08)
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection ... -
Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools.
Sabariegos, Rosario; Ortega-Prieto, Ana María; Diaz-Martínez, Luis; Grande-Pérez, Ana; García Crespo, Carlos; Gallego, Isabel; De Ávila, Ana Isabel; Albentosa-González, Laura; Soria, María Eugenia; Gastaminza, Pablo; Domingo, Esteban; Perales, Celia; Mas, Antonio[et al.] (PLOS, 2022-01-27)
In the course of experiments aimed at deciphering the inhibition mechanism of mycophenolic acid and ribavirin in hepatitis C virus (HCV) infection, we observed an inhibitory effect of the nucleoside guanosine (Gua). Here, ... -
Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.
(2023-07-18)Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular-pustular skin lesions. However, the ... -
Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models
(2020)Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway and is frequently ... -
Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.
(MDPI, 2019)Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific ... -
Interferon-stimulated genes and their antiviral activity against SARS-CoV-2.
(American Society of Microbiology, 2024)The coronavirus disease 2019 (COVID-19) pandemic remains an international health problem caused by the recent emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of May 2024, SARS-CoV-2 has ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
(ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection.
(JoVE, 2019)Despite the exceptional infectivity of the hepatitis B virus (HBV) in vivo, where only three viral genomes can result in a chronicity of experimentally infected chimpanzees, most in vitro models require several hundreds ... -
Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern.
(Nature Research, 2021)COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses ... -
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.
(The Royal Society, 2019-04-08)Hepatitis B virus (HBV) entry into hepatocytes is mediated via a high-affinity interaction between the preS1 glycoprotein and sodium/bile acid cotransporting polypeptide (NTCP). To date, in vitro model systems rely on high ... -
T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.
(Springer Nature, 2018)Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome. Analysis of ZIKV immunity is confounded by the fact that several ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
(2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...