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Listar por autor "van den Broek, Bram"
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Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
van Veen, Michiel; Matas-Rico, Elisa; van de Wetering, Koen; Leyton-Puig, Daniela; Kedziora, Katarzyna M; De Lorenzi, Valentina; Stijf-Bultsma, Yvette; van den Broek, Bram; Jalink, Kees; Sidenius, Nicolai; Perrakis, Anastassis; Moolenaar, Wouter H[et al.] (Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
Salgado-Polo, Fernando; van Veen, Michiel; van den Broek, Bram; Jalink, Kees; Leyton-Puig, Daniela; Perrakis, Anastassis; Moolenaar, Wouter H; Matas-Rico, Elisa[et al.] (The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ...