Listar por autor "García-Fernández, Maria Inmaculada"
Mostrando ítems 1-20 de 24
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, María Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
Biomarcadores en las enfermedades pulmonares interticiales difusas
Cabrera-Cesar, Eva Belen (UMA Editorial, 2017-06-20)
Las enfermedades pulmonares intersticiales difusas (EPID) representan un grupo heterogéneo de trastornos respiratorios, en su mayoría crónicos, asociados a una alta morbimortalidad. A pesar de múltiples ensayos e investigaciones ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero Zerbo, Silvana Yanina; García-Fernández, Maria Inmaculada; Santin-Nuñez, Luis Javier[et al.] (2022-07)
Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Efecto neuroprotector de fingolimod fosfato sobre el estrés oxidativo y el daño mitocondrial inducido por menadiona en neuronas dopaminérgicas en cultivo
(UMA Editorial, 2022)Las enfermedades neurodegenerativas se caracterizan por un desequilibrio en el estado oxidativo neuronal junto con un daño mitocondrial, limitando la producción de energía necesaria para realizar sus funciones neuronales. ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gómez, José Ángel; Martinez-Montañez, Elisa; Pavia-Molina, Jose; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo; García-Fernández, Maria Inmaculada[et al.] (2013-10-02)
El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Fingolimod phosphate protection against mitochondrial damage in neuronal cells
Martin-Montañez, Elisa; Álvarez-Gil, Antonio; Valverde, Nadia; Lara, Estrella; de Luque, Vanesa; Boraldi, Federica; Urbano, María; García-Fernández, Maria Inmaculada; Pavia-Molina, Jose[et al.] (Elsevier, 2019-04-17)
Background: Major role of oxidative stress in the pathogenesis of neurodegenerative diseases have been suggested, being mitochondria one of the main sources of ROS. Aim: In the present work, we have studied the antioxidant ... -
Graphene derivative scaffolds facilitate in vitro cell survival and maturation of dopaminergic SN4741 cells
Rodriguez-Losada, Noela; Wendelbo, Rune; García-Fernández, Maria Inmaculada; Pavia-Molina, Jose; Martinez-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-11-26)
The emerging carbon nanomaterial Graphene (G), in the form of scaffold structure, has an efficient bioconjugation with common biomolecules and activates cell differentiation of neuronal stem cells, providing a promising ... -
Graphene derivatives as scaffold for ex vivo survival and maturation of dopaminergic SN4741 cells.
Rodriguez-Losada, Noela; Wendelbo, Rune; García-Fernández, Maria Inmaculada; Pavia-Molina, Jose; Martin-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-09-01)
Carbon nanomaterial Graphene (G) can form a three-dimensional porous structure with efficient bioconjugation and cell differentiation properties, providing a promising scaffold for neural regeneration. Aims: To study this ... -
IGF-II AS A NEUROPROTECTIVE AND NEUROPLASTIC FACTOR IN AN OXIDATIVE DAMAGE MODEL INDUCED BY GLUCOCORTICOIDS
Lara Fernández, Estrella; Valverde, Nadia; de Luque, Vanesa; Boraldi, Federica; Santin-Nuñez, Luis Javier; Pavia-Molina, Jose; Martin-Montañez, Elisa; García-Fernández, Maria Inmaculada; Lara Fernández[et al.] (2018-10-11)
IGF-II is a pleiotropic hormone widely distributed in the CNS, which triggers its functions by binding to IGF-IR, InsulinR and IGFII / M6P (IGF-IIR) receptors. Recently, it has been proposed that the effects of IGF-II, ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera, Pablo; Valverde, Nadia; Romero Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramirez, Alicia; Pavia-Molina, Jose; Martin-Montañez, Elisa; García-Fernández, Maria Inmaculada[et al.] (2022-07-12)
Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, A.L.; García-Fernández, Maria Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, Maria Inmaculada; Gil Rodríguez, Sara; Gavito, Ana; García-Marchena, Nuria; Pedraza-Benítez, Maria del Carmen; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (2017-07-24)
Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
Mecanismos biológicos de la enfermedad intersticial pulmonar difusa. Valoración de mediadores profibróticos como potenciales biomarcadores
(UMA Editorial, 2021-04-30)Las enfermedades pulmonares intersticiales difusas (EPID) conforman un grupo heterogéneo de patologías que afectan de forma predominante al parénquima pulmonar. En las últimas décadas se han publicado estudios que han ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martin-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero Zerbo, Silvana Yanina; Millon-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santin-Nuñez, Luis Javier; Pavia-Molina, Jose; García-Fernández, Maria Inmaculada[et al.] (2022-07-20)
Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
Papel del receptor S1P sobre el estrés oxidativo mitocondrial en cultivo neuronal
Valverde, Nadia; Lara, Estrella; Álvarez-Gil, Antonio; de Luque, Vanesa; Boraldi, Federica; Pavia-Molina, Jose; Fernández, Oscar; Martin-Montañez, Elisa; García-Fernández, Maria Inmaculada[et al.] (2019-06-25)
Introducción: Fingolimod, fármaco inmunomodulador, presenta propiedades neuroprotectoras que podrían promover la recuperación de la función cognitiva en enfermedades neurodegenerativas. El estrés oxidativo parece tener un ... -
Role of Insulin-Growth Factor II on mitochondrial recovery in a cellular model of Parkinson's Disease
Valverde, Nadia; Romero Zerbo, Silvana Yanina; Lara, Estrella; Claros-Gil, Silvia; Pavia-Molina, Jose; Martin-Montañez, Elisa; García-Fernández, Maria Inmaculada[et al.] (Journal of Physiology and Biochemistry, 2022-09)
Insulin-growth factor II (IGF-II) has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. ROS causes damage to cellular macromolecules affecting several cellular processes and resulting in ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; García-Fernández, Maria Inmaculada; Chun, Jerold; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-17)
Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ... -
Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach
Moreno-Fernández, Román; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, Maria Inmaculada; Chun, Jerold; Pedraza-Benítez, Maria del Carmen; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier[et al.] (2018-07-16)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ... -
Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
Moreno-Fernández, Román; Bacq, Alexandre; Rosell-del-Valle, Cristina; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; García-Fernández, Maria Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (2019-06-25)
The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ...