Listar por autor "De los Santos-Jiménez, Juan"
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Dysregulation of glutaminase and glutamine synthetase in cancer.
Mates-Sánchez, José Manuel
; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Elsevier, 2019)
Besides fast glucose catabolism, many types of cancers are characterized by elevated glutamine consumption. Medical oncology pursuits to block specific pathways, mainly glycolysis and glutaminolysis, in tumor cells to ... -
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel (MDPI, 2024-06-20)
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Rosales, Tracy; Ko, Bookyung; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (MDPI, 2025-01-06)
Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many ... -
Glutaminases regulate glutathione and oxidative stress in cancer.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Márquez-Gómez, Javier (Springer Nature, 2020)
Targeted therapies against cancer have improved both survival and quality of life of patients. However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic mightiness. Resistant cells generate more ... -
Isoenzimas Glutaminasa en la Terapia Metabólica del Cáncer
(UMA Editorial, 2023-08-28)Las glutaminasas catalizan la conversión de glutamina a glutamato y su expresión suele estar alterada en cáncer, como parte de la reprogramación del metabolismo de la glutamina. En humanos existen dos genes que codifican ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic impact of glutaminase isoenzymes modulation on glioma cell lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Bookyung, Ko; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (2022)
Many tumors use glutamine for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. ... -
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes.
Mates-Sánchez, José Manuel; Campos-Sandoval, José Ángel; De los Santos-Jiménez, Juan; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (BenthamScience, 2020)
Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the ...