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Listar por autor "Martínez-Poveda, Beatriz"
Mostrando ítems 1-20 de 22
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El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernandez, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Quesada, Ana R.; [et al.] (2020-09-22)The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
El análogo de las estrigolactonas GR-24 induce cambios en el citoesqueleto de células tumorales y endoteliales y modula su balance rédox
Torres-Vargas, José Antonio; Martínez-Poveda, Beatriz; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2018-12-12)Las estrigolactonas son hormonas vegetales con estructura terpenoide, implicadas en el control de una serie de procesos que incluyen la inhibición de la ramificación de la raíz y el brote. Recientemente, se ha descrito el ... -
Estudios de preferencia metabólica en células del “microambiente angiogénico”
Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales-Ruiz, Jose Luis; [et al.] (2017-08-29)The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
Marrero, Ana Dácil; Martínez-Poveda, Beatriz; Castillo, Laura; Gallardo, Elena; Espartero, José L.; [et al.] (2018-09-19)Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Carrillo Fernández, Paloma; [et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis
Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2017-10-31)The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ... -
Identification and characterization of new anti-angiogenic compounds from natural sources
Carrillo, Paloma; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2017-07-21)The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ... -
Interplay between glucose and palmitate uptake in breast carcinoma in vitro
Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2018-07-17)One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ... -
La enseñanza del metabolismo: retos y oportunidades
Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; [et al.] (2017-12)Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ... -
Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?
Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2019-04-24)Metabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ... -
Metabolic preference studies in cells of the tumor microenvironment
Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-10-03)In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodriguez-Quesada, Ana Maria (2018-10-19)Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
(-)-Oleacein and (-)-oleocanthal, two phenolic compounds present in Extra Virgin Olive Oil, inhibit angiogenesis
Ortega Vidal, Juan; Salido, Sofía; Altarejos, Joaquín; Marrero, Ana Dácil; Quesada, Ana R.; [et al.] (2022-11)Phenolic compounds in the Mediterranean diet contribute to many of the health-related benefits accounted in this dietary choice. (-)-Oleocanthal and the less studied (-)-oleacein, are two phenolic compounds present in the ... -
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce, Ángel Luis; Martínez-Poveda, Beatriz; Blanco-Lopez, Angel; Quesada, Ana R.; Suarez-Marin, Maria Fernanda; [et al.] (2020-09-23)Metabolism and its regulation is one of the most complex and difficult topics for students learning biochemistry. A problem-/case-based learning (PBL) approach can be useful to help biochemistry students to fulfill the ... -
Role of glucose, glutamine and palmitate in endothelial and tumor metabolism
Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2016-12-22)Glucose and glutamine are the major sources of energy for mammalian cells. In tumors, Warburg effect and glutaminolysis have been largely studied. On the other hand, a major role of glucose in angiogenesis has been ... -
Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides
Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel; [et al.] (2018-10-15)Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ... -
Synthesis and Biological Evaluation of Depudecin Analogues
Cheng-Sánchez, Iván; Carrillo, Paloma; García-Ruiz, Cristina; Martínez-Poveda, Beatriz; Quesada, Ana R.; [et al.] (2019-09-18)(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ...