Listar por autor "Gomez-Arboledas, Angela"
Mostrando ítems 1-9 de 9
-
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sanchez-Varo, Raquel; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel
; Sanchez-Mejias, Elisabet; Jimenez, Sebastian; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Gutierrez-Perez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sanchez Mejias, Elisabeth; Mejias-Ortega, Marina; Fernandez-Valenzuela, Juan José; Gomez-Arboledas, Angela; Dávila-Cansino, José Carlos; Vitorica, Francisco Javier; Gutierrez-Perez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Romero-Molina, Carmen; Sanchez-Mejias, Elisabet; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Navarro, Victoria; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-19)
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-17)
The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sanchez-Mejias, Elisabet; Navarro, V; Jimenez, Sebastian; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Moreno-Gonzalez, Ines; Moyano, F; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Ultrastructural evidence of mitochondrial pathology in hippocampal reactive astrocytes of β-amyloidosis Alzheimer’s transgenic mice
Lopez-Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Fernandez-Valenzuela, Juan José; Gomez-Arboledas, Angela; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (Cold Spring Harbor Laboratory, 2022)
Astrocytes, the most abundant non-neuronal cell type in the CNS, play essential roles in brain homeostasis and neuroprotection, including metabolic support, synaptic plasticity, cerebral blood flow and immunity. Many of ...