Listar por autor "Peinado-Ruiz, Isabel C."
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Exposure of cancer cells to heat shock protein inhibitors induces decreased tumour survival
Burgos-Molina, Antonio Manuel
; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
All tumour studied show an increase in resistance to treatment and an increase in cell survival. This response is related to an increase in the heat shock protein HSP90, since it participates in the assembly of telomerase, ... -
Heat shock proteins overexpressed in tumour cells and their relationship with ageing and cellular resistance to treatment
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
The increase in the concentration of HSP in tumour cells produces an increase in the capacity for replication, migration, and drug resistance. HSP and HSF1 factor are involved in the etiology of breast cancer. The ... -
Increased resistance to drugs and longer life cycle by the administration of exogenous agents to normal human cells
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (2022)
Exogenous HSP70 provides protection against oxidative stress and that it could be a good therapeutic strategy to treat age-related macular degeneration. On the other hand, externally inoculating a heat shock protein to ... -
Relationship between heat shock proteins and cellular resistance to drugs and ageing
Peinado-Ruiz, Isabel C.; Burgos-Molina, Antonio Manuel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José (Elsevier, 2022-10-01)
Background and aims Ageing is a multifactorial degenerative process which causes a decrease in the cellular capacity for repair and adaptation to external stressors. In this way, it is important to maintain the proper ... -
Response of normal human cells to stress causing agents and their relationship with ageing and cellular resistance
Burgos-Molina, Antonio Manuel; Peinado-Ruiz, Isabel C.; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (, 2022)
By applying low doses of a stressor, normal cells increase the number of HSP leading to increased survival. This phenomenon is considered a cellular adaptive response. The results show that treatment with low doses of a ...