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Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus
Sánchez-Quintero, María José; Delgado, Josué; Medina-Vera, Dina; Becerra-Muñoz, Víctor Manuel; Queipo-Ortuño, María Isabel; Estévez, Mario; Plaza-Andrades, Isaac; Rodríguez Capitán, Jorge; Sánchez, Pedro L.; Crespo-Leiro, María G.; Jiménez-Navarro, Manuel Francisco; Pavón-Morón, Francisco Javier[et al.] (IOAP-MPDI, 2022-11-03)Ischemic heart disease (IHD) and type-2 diabetes mellitus (T2DM) remain major health problems worldwide and commonly coexist in individuals. Gut microbial metabolites, such as trimethylamine N-oxide (TMAO) and short-chain ... -
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
Medina-Vera, Dina; Navarro, Juan Antonio; Rivera, Patricia (WILEY, 2022-06-27)Background and Purpose Recent evidence links brain insulin resistance with neurodegenerative diseases, where hyperphosphorylated tau protein contributes to neuronal cell death. In the present study, we aimed to evaluate ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Evaluación del efecto terapéutico del d-pinitol como modificador multifacético en el curso de la enfermedad de alzheimer.
Medina-Vera, Dina (UMA Editorial, 2024)La presente tesis doctoral aborda el potencial terapéutico del nutracéutico D-Pinitol (Caromax®-D-Pinitol (DPIN)) en el contexto de la enfermedad de Alzheimer (EA), centrándose en la atenuación de la resistencia a la ... -
Multi-Omics Approach Reveals Prebiotic and Potential Antioxidant Effects of Essential Oils from the Mediterranean Diet on Cardiometabolic Disorder Using Humanized Gnotobiotic Mice.
Sánchez-Quintero, María José; Delgado, Josué; Martín-Chaves, Laura; Medina-Vera, Dina; Murri, Mora; Becerra-Muñoz, Víctor Manuel; Estévez, Mario; Crespo-Leiro, María G.; Paz López, Guillermo; González-Jiménez, Andrés; García-Ranea, Juan Antonio; Queipo-Ortuño, María Isabel; Plaza-Andrades, Isaac; Rodríguez Capitán, Jorge; Pavón-Morón, Francisco Javier; Jiménez-Navarro, Manuel Francisco[et al.] (MDPI, 2023-08-20)Essential oils sourced from herbs commonly used in the Mediterranean diet have demonstrated advantageous attributes as nutraceuticals and prebiotics within a model of severe cardiometabolic disorder. The primary objective ...