Listar por autor "Sampedro-Piquero, Patricia"
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Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Sampedro-Piquero, Patricia; Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier
(2020-03-17)
Introduction: The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier; Sampedro-Piquero, Patricia (Elsevier, 2020-08)
The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive symptomatology they ... -
Environmental enrichment results in both brain connectivity efficiency and selective improvement in different behavioral tasks
(Elsevier, 2018)Exposure to environmental enrichment (EE) has been a useful model for studying the effects of experience on brain plasticity, but to date, few is known about the impact of this condition on the brain functional networks ... -
Highlighting the role of cognitive and brain reserve in the substance use disorder field
Culuti, D; Ladrón de Guevara-Miranda, David; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier; Sampedro-Piquero, Patricia (Bentham Science Publishers, 2019)
Background: Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2019)
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Persistent drug-associated memories coexist with hippocampal-dependent cognitive decline and altered adult hippocampal neurogenesis in mice withdrawn from cocaine.
Mañas-Padilla, María del Carmen; Gil-Rodríguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-01)
Aims: Using a new animal model (‘chronic’ cocaine-induced conditioned place preference –CPP- paradigm), this work studied whether the long-term maintenance of cocaine-associated memories was concomitant to cognitive ... -
The presence of a social stimulus reduces cocaine seeking in a place preference conditioning paradigm.
Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Moreno-Fernández, Román D.; Santín-Núñez, Luis Javier (2019-09-26)
BACKGROUND: One challenge in the treatment of substance use disorders is to re-engage the interest toward non-drug-related activities. Among these activities, social interaction has had a prominent role due to its positive ... -
Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition
Mañas-Padilla, María del Carmen; Gil Rodríguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2021)
Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug seeking ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
Sampedro-Piquero, Patricia; Moreno-Fernández, Román D.; Mañas-Padilla, María del Carmen; Gil Rodríguez, Sara; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Pedraza-Benítez, María del Carmen; García-Fernández, María Inmaculada; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018)
(AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis.
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Mañas-Padilla, María del Carmen; Gil-Rodríguez, Sara; Gavito, Ana L.; Cano-Pavón, José Manuel; Pedraza-Benítez, María del Carmen; García-Fernández, María; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-07-20)
Learning experiences are potent modulators of adult hippocampal neurogenesis (AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the ... -
Treadmill exercise buffers behavioral alterations related to ethanol binge-drinking in adolescent mice.
Sampedro-Piquero, Patricia; Millón-Peñuela, Carmelo; Moreno-Fernández, Román D.; García-Fernández, María Inmaculada; Díaz-Cabiale, Zaida; Santín-Núñez, Luis Javier[et al.] (2020-07-24)
The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
Sampedro-Piquero, Patricia; Mañas-Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Springer, 2019)
The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ...