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Listar por autor "Andrade-Bellido, Raul Jesus"
Mostrando ítems 1-20 de 20
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A revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, Paul H.; Lucena-González, María Isabel; Fontana, Robert J.; Bjornsson, Einar S.; Aithal, Guruprasad P.; [et al.] (Wiley, 2022)Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network ... -
Biomarcadores en el Trasplante Hepático: Comportamiento de la Proteína C Reactiva y la Procalcitonina en el Postoperatorio Inmediato del Trasplante Hepático
Barrueco Francioni, Jesus Emilio (UMA Editorial, 2021-11-10)Introducción: el trasplante hepático (TOH) es una técnica compleja y susceptible de múltiples complicaciones entre las que destaca por su gravedad la disfunción aguda grave del injerto (DAG). Esta tesis explora en primer ... -
Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Caliz, Inmaculada; Sanabria-Cabrera, Judith; Robles-Diaz, Mercedes; [et al.] (Wiley, 2020-11-11)Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Diaz, Mercedes; Medina-Caliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; [et al.] (Elsevier, 2021-02-01)Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions
Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Caliz, Inmaculada; Sanabria-Cabrera, Judith; [et al.] (MDPI, 2021-11-15)Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ... -
Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach
González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; [et al.] (Springer, 2021-03-05)Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ... -
Esteatohepatitis no alcohólica en población adulta con rasgos de síndrome metabólico
Aguilar-Urbano, Víctor Manuel (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)La esteatohepatitis no alcohólica (NASH) es la expresión hepática del síndrome metabólico. El NASH es una entidad de pronóstico poco conocido ya que la biopsia hepática (gold standard para el diagnóstico), se realiza en ... -
Estudio de la Microbiota Intestinal en pacientes con Síndrome Metabólico y Enfermedad Hepática Grasa No Alcohólica
Martín Ocaña, Francisca (Servicio de Publicaciones y Divulgación Científica, 2016)Está claramente establecida la relación entre hígado graso y síndrome metabólico. El síndrome metabólico (SM) es un conjunto de alteraciones que identifican a los sujetos en riesgo de desarrollar diabetes y/o enfermedades ... -
Estudio de la supervivencia a largo plazo de los pacientes tratados con prótesis puente a la cirugía versus cirugía urgente en la neoplasia obstructiva maligna de colon izquierdo
Lara Romero, Carmen (UMA Editorial, 2022-01-13)Análisis de supervivencia de los pacientes potencialmente curables que presentan neoplasia maligna obstructiva izquierda. Se compara la supervivencia de los pacientes tratados con protesis puente a la cirugía versus los ... -
Estudio de los fenómenos de autoinmunidad en la enfermedad hepática tóxica
Ortega Alonso, Aida (UMA Editorial, 2017)La hepatotoxicidad idiosincrásica (DILI) por xenobióticos (fármacos, hierbas o productos de herboristería) es probablemente una de las enfermedades hepáticas más desconcertante y compleja, con múltiples facetas y gran ... -
Evaluación de causalidad en hepatotoxicidad
García-Cortés, Miren (Universidad de Málaga, Servicio de Publicaciones, 2006)La hepatotoxicidad es un problema de salud pública infranotificado debido a la ausencia de marcadores diagnósticos específicos. En las últimas décadas se han venido desarrollando distintos métodos diagnósticos en ... -
Factores Psicológicos Asociados a la Enfermedad Inflamatoria Intestinal Crónica
Lozano-Lanagrán, Marta (UMA Editorial, 2015)La Enfermedad Inflamatoria Intestinal consiste en una inflamación crónica del tracto digestivo caracterizada por periodos de remisión y brotes de actividad. Dado su carácter crónico, la impredecibilidad de su evolución y ... -
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Sanabria Cabrera, Judith Adriana; Sanjuán-Jimenéz, Rocío; Clavijo-Frutos, Encarnacion; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; [et al.] (2020)Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sanchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Diaz, Mercedes; Sanabria-Cabrera, Judith; [et al.] (Wiley, 2021-09-20)The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
Rodríguez-Agudo, Rubén; Goikoetxea-Usandizaga, Naroa; Serrano-Maciá, Marina; Fernández-Tussy, Pablo; Fernández-Ramos, David; [et al.] (IOAP-MPDI, 2022-04-30)Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without ... -
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice
Villanueva-Paz, Marina; Morán, Laura; Lopez-Alcantara, Nuria; Freixo, Cristiana; Andrade-Bellido, Raul Jesus; [et al.] (MDPI, 2021-03-05)Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratoryabnormalitiestoacuteliverfa ... -
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; [et al.] (Elsevier, 2021-12)Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith; Alvarez-Alvarez, Ismael; Robles-Diaz, Mercedes; Stankeviciute, Simona; [et al.] (Elsevier, 2021-02)Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Serious liver injury induced by Nimesulide: an international collaboration study reporting 57 cases
Bessone, Fernando; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; Gualano, Gisela; [et al.] (Springer, 2021-03-24)Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries. We aim to analyze the clinical phenotype, outcome, and histological features of nimesulide-induced liver injury (nimesulide-DILI). We ... -
Utilidad de la monitorización de niveles de fármaco en la optimización del tratamiento biológico en la enfermedad inflamatoria intestinal
Vera Rivero, Francisco Miguel (UMA Editorial, 2016)El 15% de los pacientes con enfermedad de Crohn (EC) y de colitis ulcerosa (CU) está en tratamiento con fármacos biológicos. Los anti TNF son de primera línea. Un 30% no responde a ellos, y un 40% de los que responden ...