Listar por autor "Andrades-Gómez, José Antonio"
Mostrando ítems 1-19 de 19
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A Novel Human TGF-β1 Fusion Protein in Combination with rhBMP-2 Increases Chondro-Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Claros-Gil, Silvia
; Rico-Llanos, Gustavo Adolfo; Becerra-Ratia, José; Andrades-Gómez, José Antonio (MDPI, 2014)
Transforming growth factor-beta (TGF-β) is involved in processes related to the differentiation and maturation of osteoprogenitor cells into osteoblasts. Rat bone marrow (BM) cells were cultured in a collagen-gel containing ... -
Autologous Human-Derived Bone Marrow Cells Exposed to a Novel TGF-β1 Fusion Protein for the Treatment of Critically Sized Tibial Defect.
Becerra-Ratia, José; Guerado-Parra, Enrique; Claros-Gil, Silvia; Alonso, Mónica; Bertrand, María L; González Plata, Carlos; Andrades-Gómez, José Antonio[et al.] (Taylor & Francis, 2006)
We report the first clinical case of transplantation of autologous bone marrow-derived cells in vitro exposed to a novel recombinant human transforming growth factor (rhTGF)-β1 fusion protein bearing a collagen-binding ... -
Capacitación osteogénica in vitro de células madre mesenquimales de médula ósea para su aplicación en resecciones segmentarias de hueso
(Servicio de Publicaciones y Divulgación Científica, 2015)Hasta ahora el mejor sustituto óseo es el autoinjerto, por su celularidad, osteoinducción y osteocondución, pero presenta el problema de lo limitado en cuanto a la cantidad disponible, así como a la morbilidad que genera ... -
Characterization of adult stem/progenitor cell populations from bone marrow in a three-dimensional collagen gel culture system.
Claros-Gil, Silvia; Rodríguez-Losada, Noela; Cruz, Encarnación; Guerado-Parra, Enrique; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (Sage Publications, 2012-09-01)
Stem cell transplantation therapy using mesenchymal stem cells (MSCs) is considered a useful strategy. Although MSCs are commonly isolated by exploiting their plastic adherence, several studies have suggested that there ... -
Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
Vida-Pol, Yolanda; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-Inestrosa, Ezequiel[et al.] (Royal Society of Chemistry, 2016-05-17)
Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Desarrollo de dispositivo microfluídico para la visualización del fenómeno de la extravasación leucocitaria
(2018-12-20)La microfluídica es un área de la microtecnología basada en chips de PDMS que está siendo utilizada cada vez más en multitud de aplicaciones. Una de estas aplicaciones es la investigación biomédica. La microfluídica o “Lab ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2017-06-28)
Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
Implementación de una aplicación móvil para la recopilación de datos de terapia celular en la regeneración de fracturas óseas
(2018-12-20)El tejido óseo es fundamental en nuestras vidas, es el instrumento que nos da soporte y nos permite movernos. Una lesión o enfermedad, conforme avanzamos en edad, es más difícil de solventar debido a que las células van ... -
In Vivo Bioluminescence Imaging of Cell Differentiation in Biomaterials: A Platform for Scaffold Development.
Bagó, Juli R; Aguilar, Elisabeth; Alieva, María; Soler-Botija, Carolina; Vila, Olaia F; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Becerra-Ratia, José; Rubio, Nuria; Blanco, Jerónimo[et al.] (Mary Ann Liebert, 2012-12-19)
In vivo testing is a mandatory last step in scaffold development. Agile longitudinal noninvasive real-time monitoring of stem cell behavior in biomaterials implanted in live animals should facilitate the development of ... -
Induction of superficial zone protein (SZP)/ lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-b1 and bone morphogenetic protein-7
Andrades-Gómez, José Antonio; Motaung, Shirley C; Jiménez-Palomo, Pedro; Claros-Gil, Silvia; López-Puerta, José M.; Becerra-Ratia, José; Schmid, Thomas M.; Reddi, A. Hari[et al.] (Springer Nature, 2012-04-10)
Introduction Articular cartilage (AC) is an avascular tissue with precise polarity and organization. The three distinct zones are: surface, middle and deep. The production and accumulation of the superficial zone protein ... -
Is the Articular Cartilage Regeneration Approachable Through Mesenchymal Stem Cells Therapies?
López-Puerta, José María; Zamora-Navas, Plácido; Claros-Gil, Silvia; Rico-Llanos, Gustavo Adolfo; Avedillo, Inés; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (InTech, 2013)
oday great hope is set on regenerative medicine in all medical fields. Leland Kaiser introduced the term “Regenerative Medicine” in 1992. He forecasted that a “new branch of medicine will develop that attempts to change ... -
Large-Scale Dendrimer-Based Uneven Nanopatterns for the Study of Local RGD Density Effects on Cell Adhesion
Lagunas, Anna; Castaño, Albert G; Artés, Juan M; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-Inestrosa, Ezequiel; Gorostiza, Pau; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Samitier, Josep[et al.] (2014)
Cell adhesion processes are governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected by local rather than global concentrations of cell adhesive ligands. In many cell-based studies, ... -
Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy
Villatoro, Antonio J; Fernández, Viviana; Claros-Gil, Silvia; Alcoholado Cueto, Cristina; Cifuentes-Rueda, Manuel; Merayo-Lloves, Jesús; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (MDPI, 2017)
Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is ... -
RGD peptide on Dendrimer surfaces Affects Mesenchymal Stem Cells Adhesion
Vida-Pol, Yolanda; Molina, Noemi; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Lagunas, Anna; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2016-04-07)
Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment
Villatoro, Antonio J; Claros-Gil, Silvia; Fernández, Viviana; Alcoholado Cueto, Cristina; Fariñas Guerrero, Fernando; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (BioMed Central, 2018)
Background: Feline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therapeutic ... -
Selection and induction of rat skeletal muscle-derived cells to the chondro-osteogenic lineage.
Claros-Gil, Silvia; Alonso, Mónica; Becerra-Ratia, José; Andrades-Gómez, José Antonio (CMB Association, 2008-10-26)
Bone marrow (BM) has been long established as the main source of pluripotential mesenchymal stem cells (MSCs), and has been so far the main recognized source of osteoprogenitor cells that ... -
Tenocytic induction of stem cells from bone marrow on polymeric microparticles for a new concept of tendon regenerative prosthesis
Claros-Gil, Silvia; Araque-Monrós, Mª Carmen; Rodríguez-Losada, Noela; Gil-Santos, Luis; Monleón-Pradas, Manuel; Más-Estellés, Jorge; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (2015-10-26)
A new concept of a regenerative and resorbable prosthesis for tendon and ligament has been developed. The prosthesis consists of a poly-lactide acid (PLA) braid, microparticles in its interior serving as cell carriers, and ... -
The effect of type I collagen on osteochondrogenic differentiation in adipose-derived stromal cells in vivo.
Alonso, Mónica; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio (Elsevier, 2008)
Background The objective of this study was to investigate whether type I collagen would elicit in vivo bone formation of passaged rat adipose-derived adult stromal cells (ADASC) placed extraskeletally. Methods After ... -
Use of Adipose-Derived Mesenchymal Stem Cells in Keratoconjunctivitis Sicca in a Canine Model
Villatoro, Antonio J.; Fernández, Viviana; Claros-Gil, Silvia; Rico-LLanos, Gustavo Adolfo; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (Wiley, 2015)
Keratoconjunctivitis sicca (KCS) or dry eye disease (DED) is an immune-mediated multifactorial disease, with high level of prevalence in humans and dogs. Our aim in this study was to investigate the therapeutic effects of ...