Listar por autor "Ruiz-Cabello, Francisco"
Mostrando ítems 1-3 de 3
-
Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)
Pachkoria, K.; Lucena-González, María Isabel
; Ruiz-Cabello, Francisco; Crespo, Esperanza; Cabello-Porras, María Rosario; Andrade-Bellido, Raúl Jesús[et al.] (2007-01-29)
Background and purpose: The general view on the pathogenesis of drug-induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sánchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana; Ortega-Alonso, Aida; García-Cortés, Miren; González-Grande, Rocío; Jiménez-Pérez, Miguel; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Wiley, 2021-09-20)
The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury
Ulzurrun, Eugenia; Stephens, Camilla; Crespo, Esperanza; Ruiz-Cabello, Francisco; Ruiz-Nuñez, Julia; Saenz-López, Pablo; Moreno-Herrera, Inmaculada; Robles-Díaz, María Mercedes; Hallal, Hacibe; Moreno-Planas, José María; Cabello-Porras, María Rosario; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús[et al.] (WILEY, 2013-04)
Background & aims: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug-induced liver injury ...