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Listar por autor "Bermúdez Silva, Francisco Javier"
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Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage
González-Mariscal, Isabel; Pozo-Morales, Macarena; Romero-Zerbo, Silvana Yanina; Espinosa-Jiménez, Vanesa; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Cobo-Vuilleumier, Nadia; Gauthier, Benoit R.; Bermúdez Silva, Francisco Javier[et al.] (Elsevier, 2021-12-03)The atypical cannabinoid Abn-CBD improves the inflammatory status in preclinical models of several pathologies, including autoimmune diseases. However, its potential for modulating inflammation in autoimmune type 1 diabetes ... -
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Blanco-Calvo, Eduardo; Bilbao, Ainhoa; Luque-Rojas, María Jesús; Palomino, Ana; Bermúdez Silva, Francisco Javier; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; Gutiérrez-Pérez, Antonia; Campos-Sandoval, José A.; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)Lysophosphatidic acid is a phospholipid mediator that modulates neurodevelopment and neurogenesis in the hippocampus through its actions on LPA1 receptors. Emerging evidences support LPA1 as a mediator of learning and ... -
Cannabinoids, eating behaviour, and energy homeostasis
Romero-Zerbo, Silvana Yanina; Bermúdez Silva, Francisco Javier (John Wiley & Sons, 2014)Soon after the discovery of cannabis by western societies, its psychotropic effects overshadowed its medical benefits. How-ever, investigation into the molecular action of the main constituents of cannabis has led to the ... -
Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.
Suárez-Pérez, Juan; Llorente, Ricardo; Romero-Zerbo, Silvana Yanina; Mateos, Beatriz; Bermúdez Silva, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Paz Viveros, Maria; Suárez-Pérez, Juan[et al.] (Wiley, 2009)Early maternal deprivation (MD) in rats (24 h, postnatal day 9–10) is a model for neurodevelopmental stress. There are some data proving that MD affects the endocannabinoid system (ECS) in a gender-dependent manner, and ... -
Los receptores CB1 y GPR55 en la fisiología del islote pancreático y en la fisiopatología de la diabetes tipo 2
Ruz-Maldonado, Inmaculada (UMA Editorial, 2017-05-26)La diabetes tipo 2 (T2D), es una enfermedad caracterizada por hiperglucemia, debida a una combinación entre resistencia a la insulina y una progresiva disfunción y pérdida de masa de las células β que impide compensarla ... -
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo-Vuilleumier, Nadia; Lorenzo, Petra I; García Rodríguez, Noelia; Herrera Gómez, Irene de Gracia; Fuente-Martin, Esther; López-Noriega, Livia; Mellado-Gil, José Manuel; Romero-Zerbo, Silvana Yanina; Baquié, Mathurin; Lachaud, Christian Claude; Stifter, Katja; Perdomo, German; Bugliani, Marco; De Tata, Vincenzo; Bosco, Domenico; Parnaud, Geraldine; Pozo, David; Hmadcha, Abdelkrim; Florido, Javier P; Toscano, Miguel G; de Haan, Peter; Schoonjans, Kristina; Sánchez Palazón, Luis; Marchetti, Piero; Schirmbeck, Reinhold; Martín-Montalvo, Alejandro; Meda, Paolo; Bernat, Soria; Bermúdez Silva, Francisco Javier; St-Onge, Luc; Gauthier, Benoit R[et al.] (Nature Research, 2018)Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana Yanina; García Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez Silva, Francisco Javier; Murri, Mora; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2019)Objective: This study aimed to analyze the potential association of different microRNA (miRNA) moleculeswith both type 2 diabetes (T2D) and obesity and determine their target genes.Methods: Quantitative PCR was used to ... -
Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice
Romero-Zerbo, Silvana Yanina; Garcia-Gutierrez, M S; Suárez-Pérez, Juan; Rivera, Patricia; Ruz-Maldonado, Inmaculada; Vida, M.; Rodriguez-de-Fonseca, Fernando; Manzanares, Jorge; Bermúdez Silva, Francisco Javier[et al.] (Blackwell Publishing Ltd, 2009)t is well known that the endocannabinoid system, through cannabinoid CB1 receptor activation,has an important role in the main aspects of energy balance (i.e. food intake, energy expenditureand glucose and fat metabolism), ... -
Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study
Ruiz-García, Ignacio; Ortiz-Flores, Rodolfo; Badía, Rocío; García-Borrego, Aranzazu; García-Fernández, María Inmaculada; Lara, Estrella; Martín-Montañez, Elisa; García Serrano, Sara; Valdés, Sergio; Gonzalo, Montserrat; Tapia Guerrero, María José; Fernández-García, José Carlos; Sánchez-García, Alicia; Muñoz-Cobos, Francisca; Calderón-Cid, Miguel; El-Bekay, Rajaa; Covas, María-Isabel; Rojo-Martínez, Gemma; Olveira-Fuster, Gabriel María; Romero-Zerbo, Silvana Yanina; Bermúdez Silva, Francisco Javier[et al.] (Elsevier, 2023)Background: Oleocanthal and oleacein are olive oil phenolic compounds with well known anti inflammatory and anti-oxidant properties. The main evidence, however, is provided by experimental studies. Few human studies have ... -
RPL13A and EEF1A1 Are Suitable Reference Genes for qPCR during Adipocyte Differentiation of Vascular Stromal Cells from Patients with Different BMI and HOMA-IR
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Oliva Olivera, Wilfredo; Zayed, Hatem; Vega-Rioja, Antonio; Monteseirin, Javier; Romero-Zerbo, Silvana Yanina; Tinahones-Madueño, Francisco José; Bermúdez Silva, Francisco Javier; El-Bekay, Rajaa[et al.] (Public Library of Science, 2016)Real-time or quantitative PCR (qPCR) is a useful technique that requires reliable reference genes for data normalization in gene expression analysis. Adipogenesis is among the biological processes suitable for this technique. ... -
The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease
Romero-Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Espinosa-Jiménez, Vanesa; Pozo-Morales, Macarena; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Lara, Estrella; Cobo-Vuilleumier, Nadia; Rafacho, Alex; Olveira-Fuster, Gabriel María; Rojo-Martínez, Gemma; Gauthier, Benoit R.; González-Mariscal, Isabel; Bermúdez Silva, Francisco Javier[et al.] (Frontiers, 2020-03-06)Background and Aims: The synthetic atypical cannabinoid Abn-CBD, a cannabidiol (CBD) derivative, has been recently shown to modulate the immune system in different organs, but its impact in obesity-related meta-inflammation ... -
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice
Bermúdez Silva, Francisco Javier; Romero-Zerbo, Silvana Yanina; Haissaguerre, Magalie; Ruz-Maldonado, Inmaculada; Lhamyani, Said; El-Bekay, Rajaa; Tabarin, Antoine; Marsicano, Giovanni; Cota, Daniela[et al.] (The Company of Biologists, 2016)The endocannabinoid system (ECS) is an intercellular signalling mechanism that is present in the islets of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream ... -
The role of the endocannabinoid system in eating disorders: pharmacological implications
Marco, Eva-María; Romero-Zerbo, Silvana Yanina; Paz Viveros, María; Bermúdez Silva, Francisco Javier (Wolters Kluwer Health, 2012)The endocannabinoid (eCB) system is a widespread intercellular signalling mechanism that plays a critical role in body homoeostasis. It is located in key points involved in food intake and energy expenditure, coordinating ... -
Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids.
Suárez-Pérez, Juan; Romero-Zerbo, Silvana Yanina; Márquez, Lucia; Rivera, Patricia; Iglesias, Mar; Bermúdez Silva, Francisco Javier; Andreu, Montserrat; Rodriguez-de-Fonseca, Fernando[et al.] (PLOS, 2012)Studies in animal models and humans suggest anti-inflammatory roles on the N-acylethanolamide (NAE)-peroxisome proliferators activated receptor alpha (PPARα) system in inflammatory bowel diseases. However, the presence and ...