Listar por autor "Ortega-Prieto, Ana Maria"
Mostrando ítems 1-8 de 8
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3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection.
(Springer-Nature, 2018-02-14)With more than 240 million people infected, hepatitis B virus (HBV) is a major health concern. The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose ... -
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
(Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ... -
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis
Ortega-Prieto, Ana Maria; Sheldon, Julie; Grande-Pérez, Ana
; Tejero, Hector; Gregori, Josep; Quer, Josep; Esteban, Juan I.; Domingo, Esteban; Perales, Celia[et al.] (PLOS One, 2013-08)
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection ... -
Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.
(2023-07-18)Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular-pustular skin lesions. However, the ... -
Interferon-stimulated genes and their antiviral activity against SARS-CoV-2.
(American Society of Microbiology, 2024)The coronavirus disease 2019 (COVID-19) pandemic remains an international health problem caused by the recent emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of May 2024, SARS-CoV-2 has ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
(ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection.
(The Royal Society, 2019-04-08)Hepatitis B virus (HBV) entry into hepatocytes is mediated via a high-affinity interaction between the preS1 glycoprotein and sodium/bile acid cotransporting polypeptide (NTCP). To date, in vitro model systems rely on high ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
(2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...