• El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo 

      Carrillo, Paloma; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2016-10-03)
      Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ...
    • Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention 

      Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales-Ruiz, Jose Luis; [et al.] (2017-08-29)
      The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ...
    • Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2017-10-31)
      The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ...
    • Identification and characterization of new anti-angiogenic compounds from natural sources 

      Carrillo, Paloma; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Quesada, Ana R. (2017-07-21)
      The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ...
    • Interplay between glucose and palmitate uptake in breast carcinoma in vitro 

      Ocaña, Mª Carmen; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel (2018-07-17)
      One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ...
    • Study of the antitumor potential of stauprimide in breast cancer 

      Carrillo, Paloma; Téllez Quijorna, Clara; Bernal, Manuel; Rodríguez Quesada, Ana; Medina Torres, Miguel Ángel; [et al.] (2021)
      Stauprimide, a semi-synthetic derivative of staurosporine, was characterized in 2009 as a potent differentiation-enhancing compound in embryonic stem cells [1]. Although it was first thought that this compound could maintain ...
    • Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides 

      Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel; [et al.] (2018-10-15)
      Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ...
    • Synthesis and Biological Evaluation of Depudecin Analogues 

      Cheng-Sánchez, Iván; Carrillo, Paloma; García-Ruiz, Cristina; Martínez-Poveda, Beatriz; Quesada, Ana R.; [et al.] (2019-09-18)
      (-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ...