Listar por autor "Gutiérrez-Pérez, Antonia"
Mostrando ítems 1-20 de 66
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2011 Año de la Investigación en el Alzheimer
Gutiérrez-Pérez, Antonia
(Universidad de Málaga, Facultad de Ciencias, 2011)
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabet; Jimenez, Sebastian; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gomez-Arboledas, Angela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez-Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Nunez-Diaz, Cristina; Forner, Stefania; Martini, Alessandra; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-Gonzalez, Ines; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Minh Thu Nguyen, Marie; Baglietto-Vargas, David; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Moreno-Gonzalez, Ines; Soto, Claudio; Shahnawaz, Mohammad; Da Cunha, Celia; Forner, Stefania; Nunez-Diaz, Cristina; Pham Tran, Janine; Cheung, Alwin; Do Huynh, Kelly; Martinie, Alessandra C.[et al.] (Cold Spring Harbor Laboratory, 2020-12-02)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Navarro, Victoria; Jimenez, Sebastian; Sánchez-Mejías, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Aplicación de estrategias de aprendizaje para la adquisición de competencias profesionales y su evaluación mediante una rúbrica integradora en diversos títulos de grado de la Universidad de Málaga
Santacruz-Cruz, María Isabel; Díaz-Ramos, Antonio; López-Guerrero, María del Mar; Aranda-Garrido, María Lourdes; Martin-Valero, Rocio; Ruiz-Parraga, Gema Teresa; Jiménez-Lara, Antonio Jesús; Gutiérrez-Pérez, Antonia[et al.] (2015-07-28)
El Espacio Europeo de Educación Superior ha supuesto importantes cambios en el proceso de enseñanza-aprendizaje para la adquisición de competencias transversales y específicas. La calidad es un factor estratégico, por lo ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sanchez Mejias, Elisabeth; Mejias-Ortega, Marina; Fernández-Valenzuela, Juan José; Gomez-Arboledas, Angela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Bone marrow-derived mesenchymal stem cells transplantation produces a tissue recovery in hydrocephalic mice
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2018-07-25)
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated to ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction, which cause significant mortality and life-long neurological ... -
Brain tissue recovery in obstructive congenital hydrocephalus after intraventricular transplantation of mesenchymal stem cells
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (2018-10-29)
Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when transplanted. The aim of this study was to ... -
Caracterización de la patología amiloide y su relación con la microglía en modelos transgénicos de la enfermedad de Alzheimer
(UMA Editorial, 2020-02-24)En la enfermedad de Alzheimer, la acumulación de beta-amiloide (Abeta) y de fosfo-tau, principales lesiones de esta enfermedad, va acompañada de una respuesta inflamatoria con activación microglial y astroglial. Variantes ... -
Caracterización neuropatológica y evaluación preclínica de potenciales estrategias terapéuticas en modelos animales transgénicos de la enfermedad de Alzheimer
Trujillo-Estrada, Laura Isabel (Servicio de Publicaciones y Divulgación Científica, 2015)
La enfermedad de Alzheimer (EA), principal causa de demencia en personas mayores de 65 años, constituye uno de los problemas socio-sanitarios más importantes de nuestra época. Su etiología no es conocida y, actualmente, ... -
Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology.
Cáceres Palomo, Laura; García-León, Juan Antonio; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
Sánchez-Mejías, Elisabet; Mejias-Ortega, Marina; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier (Wiley, 2021)
Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabet; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura Isabel; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernández-Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; Sánchez-Mejías, Elisabet; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-11-03)
Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Conformational Aβ strains and cross-seeding mechanism in Alzheimer’s disease pathogenesis: In vivo studies in transgenic animal models
(UMA Editorial, 2022)Accumulation of amyloid-beta (Aβ) fibrils in the brain is associated with Alzheimer’s disease (AD) pathology. These fibrils exhibit distinct conformations or “strains” as consequence of variations in their molecular ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
(UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sánchez-Mejías, Elisabet; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Sánchez-Varo, Raquel María; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ...