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Listar por autor "Gutierrez-Perez, Antonia"
Mostrando ítems 1-20 de 44
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2011 Año de la Investigación en el Alzheimer
Gutierrez-Perez, Antonia (Universidad de Málaga, Facultad de Ciencias, 2011) -
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sanchez-Varo, Raquel; De Castro, Vanessa; Trujillo-Estrada, Laura; Sanchez-Mejias, Elisabeth; Jimenez, Sebastian; [et al.] (2017-10-02)We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; [et al.] (2020-12-17)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
Trujillo-Estrada, Laura; Minh Thu Nguyen, Marie; Baglietto-Vargas, David; LaFerla, Frank; Gutierrez-Perez, Antonia; [et al.] (Cold Spring Harbor Laboratory, 2020-12-02)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sánchez-Mejias, Elisabeth; [et al.] (2017-10-04)Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Aplicación de estrategias de aprendizaje para la adquisición de competencias profesionales y su evaluación mediante una rúbrica integradora en diversos títulos de grado de la Universidad de Málaga
Santacruz-Cruz, Maria Isabel; Díaz-Ramos, Antonio; López-Guerrero, María del Mar; Aranda-Garrido, Maria Lourdes; Martín-Valero, Rocío; [et al.] (2015-07-28)El Espacio Europeo de Educación Superior ha supuesto importantes cambios en el proceso de enseñanza-aprendizaje para la adquisición de competencias transversales y específicas. La calidad es un factor estratégico, por lo ... -
Bone marrow-derived mesenchymal stem cells transplantation produces a tissue recovery in hydrocephalic mice
García-Bonilla, María; Shumilov, Kirill; Vitorica, Javier; García-Martín, María Luisa; Muñoz, Carmen; [et al.] (2018-07-25)In congenital hydrocephalus, cerebrospinal fluid accumulation is associated to ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction, which cause significant mortality and life-long neurological ... -
Brain tissue recovery in obstructive congenital hydrocephalus after intraventricular transplantation of mesenchymal stem cells
García-Bonilla, María; Ojeda-Pérez, B.; Shumilov, Kirill; Vitorica, J.; García-Martín, María Luisa; [et al.] (2018-10-29)Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when transplanted. The aim of this study was to ... -
Caracterización de la patología amiloide y su relación con la microglía en modelos transgénicos de la enfermedad de Alzheimer
Nuñez Diaz, Cristina (UMA Editorial, 2020-02-24)En la enfermedad de Alzheimer, la acumulación de beta-amiloide (Abeta) y de fosfo-tau, principales lesiones de esta enfermedad, va acompañada de una respuesta inflamatoria con activación microglial y astroglial. Variantes ... -
Caracterización neuropatológica y evaluación preclínica de potenciales estrategias terapéuticas en modelos animales transgénicos de la enfermedad de Alzheimer
Trujillo Estrada, Laura Isabel (Servicio de Publicaciones y Divulgación Científica, 2015)La enfermedad de Alzheimer (EA), principal causa de demencia en personas mayores de 65 años, constituye uno de los problemas socio-sanitarios más importantes de nuestra época. Su etiología no es conocida y, actualmente, ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Davila, Jose Carlos; Gutierrez-Perez, Antonia; Vitorica, Javier (Wiley, 2021)Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabeth; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura; Sanchez-Varo, Raquel; [et al.] (2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Conformational Aβ strains and cross-seeding mechanism in Alzheimer’s disease pathogenesis: In vivo studies in transgenic animal models
Gomez Gutierrez, Ruben (UMA Editorial, 2022)Accumulation of amyloid-beta (Aβ) fibrils in the brain is associated with Alzheimer’s disease (AD) pathology. These fibrils exhibit distinct conformations or “strains” as consequence of variations in their molecular ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
Fernandez Valenzuela, Juan José (UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabeth; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; [et al.] (2019-07-18)The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabeth; [et al.] (2018-07-20)AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Romero-Molina, Carmen; Sanchez-Mejias, Elisabeth; Gomez-Arboledas, Angela; [et al.] (2019-07-19)Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura; Vizuete, María Luisa; [et al.] (2022)Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice
Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco; Vizuete, Marisa; [et al.] (2016-09-09)AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ... -
Estudio del proceso neurodegenerativo en la corteza entorrinal del modelo transgénico murino PS1M146LxAPP751SLde la enfermedad de Alzheimer
Moreno González, Inés (Universidad de Málaga, Servicio de Publicaciones, 2009)