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Listar por autor "Gutierrez-Perez, Antonia"
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Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabeth; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura; Sanchez-Varo, Raquel; [et al.] (2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
Fernandez-Valenzuela, Juan Jose (UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabeth; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; [et al.] (2019-07-18)The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabeth; [et al.] (2018-07-20)AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan Jose; Romero-Molina, Carmen; Sanchez-Mejias, Elisabeth; Gomez-Arboledas, Angela; [et al.] (2019-07-19)Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
In vitro modeling of dysfunctional glial cells in neurodegenerative diseases using human pluripotent stem cells
García León, Juan; Eggermont, K; Neyrinck, K; Davila, Jose Carlos; Vitorica, Javier; [et al.] (2019-07-26)Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sanchez-Mejias, Elisabeth; Navarro, Victoria; Nuñez-Diaz, Cristina; Jiménez, Sebastián; Sanchez-Varo, Raquel; [et al.] (2018-07-20)Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; [et al.] (2019-07-17)The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ...