Listar por autor "Fuxe, Kjell"
Mostrando ítems 1-20 de 69
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A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millón-Peñuela, Carmelo
; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narvaez, Jose Angel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Oxford Academic, 2015-02-16)
Galanin (GAL) plays a role in mood regulation. In this study we analyzed the action of the active N-terminal fragment [GAL(1–15)] in anxiety- and depression-related behavioral tests in rats. Methods: The effect of ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2017-08-30)
Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion
Díaz-Sánchez, Estela; López-Salas, Alexander; Mirchandani-Duque, Marina; Álvarez-Contino, José Erik; Sánchez-Pérez, José Andrés; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (Elsevier, 2023)
Different brain regions’ interactions have been implicated in relevant neurological diseases, such as major depressive disorder (MDD), anxiety disorders, age-dependent cognitive decline, Alzheimer’s disease (AD) and addiction. ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramírez, Alicia; Suárez-Boomgaard, Diana; Gago-Calderón, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; Roales-Buján, Ruth; Fuxe, Kjell; De-la-Calle-Martín, Adelaida[et al.] (2013)
Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago-Calderón, Belén; Flores-Burgess, Antonio; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; García-Durán, Laura[et al.] (2019-09-10)
Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Allén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2019-09-12)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
García-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2021-01-22)
The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela, Dasiel; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Taylor & Francis, 2024-04-21)
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating condition, necessitating novel therapeutic strategies due to the limited efficacy and adverse effects of current treatments. We explored how galanin ... -
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.
Sánchez-Varo, Raquel María; López-Salas, Alexander; Rasiel, Beltran-Casanueva; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (Springer Nature, 2024-03-28)
Background: Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This ... -
Evidence for a synergistic effect of NPY1R agonist co-administered with Ketamine in rats: relevance to neurodegenerative and mood disorders.
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Beltrán-Casanueva, Rasiel; Hernández-García, Aracelis; Bayolo-Guanche, Juan Vicente; Romero-Imbroda, Jesús; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Serrano-Castro, Pedro; Narváez-Peláez, Manuel[et al.] (2024)
Introduction/Objetives: Major depressive disorder is one of the most prevalent health problems worldwide and its current therapeutic approach still generates great dissatisfaction due to its limited efficacy, unwanted ... -
Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations
Narváez-Peláez, Manuel; Andrade-Talavera, Yunieski; Valladolid-Acebes, Ismael; Fredriksson, Magnus; Siegele, Pia; Hernandez-Sosa, Alejandro; Fisahn, André; Fuxe, Kjell; Borroto-Escuela, Dasiel O.[et al.] (Elsevier, 2020-06-15)
The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant ... -
GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
Galanin (1-15) and escitalopram combination in rats reduces alcohol consumption in the ethanol self-administration test and improves escitalopram effects in the forced swimming test.
Cantero-García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; García-Durán, Laura; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2022-07-12)
Recently, we described that Galanin(1-15)[GAL(1-15)] enhanced Escitalopram(ESC) effectiveness in depression symptoms. Moreover GAL(1-15) induces a substantial reduction in alcohol consumption. To investigate the effect of ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Puigcerver-Martínez, Araceli; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2019-06-17)
Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2017)
The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ...