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Listar por autor "Jiménez-Lara, Antonio Jesús"
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A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis.
Rodríguez-Pérez, Luis Manuel; López-de-San-Sebastián, Javier; De-Diego-Barbado, Isabel
; Smith-Fernández, José Aníbal
; Roales-Buján, Ruth; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
[et al.] (Frontiers, 2024-02-21)
INTRODUCTION Dysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital ... -
A sequential cell therapy to recover the ependymal cells in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
(2022-09)
Background Germinal matrix haemorrhages and intraventricular haemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a relevant cause of morbidity and mortality in the premature neonatal population. The ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María; Trujillo-Estrada, Laura Isabel
; Sánchez-Mejías, Elisabeth
; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús
; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia
[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Aplicación de estrategias de aprendizaje para la adquisición de competencias profesionales y su evaluación mediante una rúbrica integradora en diversos títulos de grado de la Universidad de Málaga
Santacruz-Cruz, María Isabel; Díaz-Ramos, Antonio
; López-Guerrero, María del Mar
; Aranda-Garrido, María Lourdes
; Martín-Valero, Rocío
; Ruiz-Párraga, Gema Teresa
; Jiménez-Lara, Antonio Jesús
; Gutiérrez-Pérez, Antonia
[et al.] (2015-07-28)
El Espacio Europeo de Educación Superior ha supuesto importantes cambios en el proceso de enseñanza-aprendizaje para la adquisición de competencias transversales y específicas. La calidad es un factor estratégico, por lo ... -
Aplicación de una terapia celular basada en células madre mesenquimales en un modelo animal de hidrocefalia congénita
García Bonilla, María (UMA Editorial, 2020-01-08)La hidrocefalia congénita es una condición patológica caracterizada por la acumulación de líquido cefalorraquídeo, con unas manifestaciones fisiopatológicas que incluyen: dilatación de los ventrículos cerebrales ... -
Bone marrow-derived mesenchymal stem cells characterization and transplantation in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Santos-Ruiz, Leonor
; Shumilov, Kirill; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús
[et al.] (2015-10-08)
Congenital hydrocephalus is a disorder presenting a degeneration of the periventricular cerebral parenchyma and the white matter, which causes significant mortality and life-long neurological complications. There are ... -
Bone marrow-derived mesenchymal stem cells transplantation produces a tissue recovery in hydrocephalic mice
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia
; Jiménez-Lara, Antonio Jesús
[et al.] (2018-07-25)
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated to ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction, which cause significant mortality and life-long neurological ... -
Brain tissue recovery in obstructive congenital hydrocephalus after intraventricular transplantation of mesenchymal stem cells
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
[et al.] (2018-10-29)
Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when transplanted. The aim of this study was to ... -
Characterization and administration of bone marrow-derived mesenchymal stem cells in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Shumilov, Kirill; Santos-Ruiz, Leonor
; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús
[et al.] (2015-07-08)
Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool in neurodegenerative diseases, due to their ability to migrate to degenerated tissues and the production of growth factors. ... -
Desarrollo del epéndimo y subepéndimo en modelos animales en condiciones normales y en la hidrocefalia congénita
Rodríguez-Pérez, Luis Manuel(Servicio de Publicaciones y Divulgacion Cientifica, 2016)
La presente Tesis Doctoral se ha diseñado para responder a las siguientes hipótesis: 1.- El programa de diferenciación de la zona ventricular que se afecta en el ratón hyh pone de manifiesto que la población celular que ... -
Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages
Rodríguez-Pérez, Luis Manuel; Ojeda-Pérez, Betsaida; López-de-San-Sebastián, Javier; García-Bonilla, María; González-García, Marcos; Fernandez-Muñoz, Beatriz; Sánchez Pernaute, Rosario; García-Martín, María L.; Domínguez-Pinos, Dolores
; Cárdenas García, Casimiro; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
[et al.] (AHA/ASA Journals, 2024-04)
BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia
; Andrades-Gómez, José Antonio
; Guitérrez, Antonia; Páez-González, Patricia
; Jiménez-Lara, Antonio Jesús
[et al.] (2017-06-28)
Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
Estudio de la diferenciación in vitro de progenitores ependimarios en condiciones de hidrocefalia posthemorrágica y en cotrasplante con células madre mesenquimales
El epéndimo es el epitelio que recubre las paredes del sistema ventricular cerebral, y cumple importantes funciones relacionadas con el mantenimiento y homeostasis del sistema nervioso central. Por su ubicación, el ... -
Generation of periventricular reactive astrocytes overexpressing aquaporin 4 Is stimulated by mesenchymal stem cell therapy
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Rodríguez-Pérez, Luis Manuel; Domínguez-Pinos, Dolores
; Vitorica Ferrández, Javier; Jiménez, Sebastián; Ramírez-Lorca, Reposo; Echevarría, Miriam; Cárdenas García, Casimiro; Iglesias, Teresa; Gutiérrez-Pérez, Antonia
; McAllister, James P. (II); Limbrick, David D. (Jr.); Páez-González, Patricia
; Jiménez-Lara, Antonio Jesús
[et al.] (MDPI, 2023-03-15)
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. Congenital hydrocephalus is associated with a reaction of astrocytes in the periventricular white ... -
Human Mesenchymal Stem Cells and its Exosomes in Posthemorrhagic Hydrocephalus: A Focus on Edema and Ependymal Repair
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
(SRHSB 2024 Annual Conference, 2023-09-04)
Background Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) often lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH is known to ... -
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Ojeda-Pérez, Betsaida; Campos-Sandoval, José Ángel; García-Bonilla, María; Cárdenas García, Casimiro; Páez-González, Patricia
; Jiménez-Lara, Antonio Jesús
[et al.] (BMC, 2021)
Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most ... -
IPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus
Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) ... -
iPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus
Rodríguez-Pérez, Luis Manuel; Hidalgo-Díaz, Juan Antonio; Jiménez-Lara, Antonio Jesús
; Páez-González, Patricia
(2019-07-03)
Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) ... -
Learning strategies for the acquisition of specific skills, and its evaluation through an integrated rubric in several degrees of University of Malaga (Spain).
Santacruz-Cruz, María Isabel; Díaz-Ramos, Antonio
; López-Guerrero, María del Mar
; Aranda-Garrido, María Lourdes
; Martín-Valero, Rocío
; Ruiz-Párraga, Gema Teresa
; Gutiérrez-Pérez, Antonia
; Jiménez-Lara, Antonio Jesús
[et al.] (2015-07-28)
It is essential for the university lecturers/professors to design new strategies that help students to acquire skills in the new framework of the European Higher Education Area. Furthermore, the assessment of the effectiveness ... -
Long-time effects of an experimental therapy with mesenchymal stem cells in congenital hydrocephalus
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Vitorica Ferrández, Javier; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús
[et al.] (2019-07-03)
Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when they are transplanted in other neurodegenerative ...