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Los receptores CB1 y GPR55 en la fisiología del islote pancreático y en la fisiopatología de la diabetes tipo 2
Ruz-Maldonado, Inmaculada (UMA Editorial, 2017-05-26)La diabetes tipo 2 (T2D), es una enfermedad caracterizada por hiperglucemia, debida a una combinación entre resistencia a la insulina y una progresiva disfunción y pérdida de masa de las células β que impide compensarla ... -
NG2 cells in an animal model of congenital hydrocephalus
Jiménez-Lara, Antonio Jesús; Ojeda-Pérez, Betsaida; García-Bonilla, María; Ruz-Maldonado, Inmaculada; Mateos-Grondona, Jesús; Rodríguez-Pérez, Luis Manuel; Páez-González, Patricia[et al.] (2017-06-28)NG2 cells are considered oligodendrocyte precursor cells (OPC). In pathological conditions, NG2 cells contribute to generate oligodendrocytes and reactive astrocytes. This study has been designed to uncover the role of NG2 ... -
Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice
Romero-Zerbo, Silvana Yanina; Garcia-Gutierrez, M S; Suárez-Pérez, Juan; Rivera, Patricia; Ruz-Maldonado, Inmaculada; Vida, M.; Rodriguez-de-Fonseca, Fernando; Manzanares, Jorge; Bermúdez Silva, Francisco Javier[et al.] (Blackwell Publishing Ltd, 2009)t is well known that the endocannabinoid system, through cannabinoid CB1 receptor activation,has an important role in the main aspects of energy balance (i.e. food intake, energy expenditureand glucose and fat metabolism), ... -
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice
Bermúdez Silva, Francisco Javier; Romero-Zerbo, Silvana Yanina; Haissaguerre, Magalie; Ruz-Maldonado, Inmaculada; Lhamyani, Said; El-Bekay, Rajaa; Tabarin, Antoine; Marsicano, Giovanni; Cota, Daniela[et al.] (The Company of Biologists, 2016)The endocannabinoid system (ECS) is an intercellular signalling mechanism that is present in the islets of Langerhans and plays a role in the modulation of insulin secretion and expansion of the β-cell mass. The downstream ...