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Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Nualart, Francisco; Cifuentes-Rueda, Manuel; Ramírez, Eder; Martínez, Fernando; Barahona, M José; Ferrada, Luciano; Saldivia, N; Borgonzone, Ernesto R; Thorens, B; Salazar, Katterine[et al.] (Public Library of Science, 2023-09)
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ... -
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
Baeza, Víctor; Cifuentes-Rueda, Manuel; Martínez, Fernando; Ramírez, Eder; Nualart, Francisco; Ferrada, Luciano; Oviedo, María José; De Lima, Isabelle; Troncoso, Ninoschka; Saldivia, Natalia; Salazar, Katty[et al.] (Springer Nature, 2021)
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such ...