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Listar por autor "Ávila-Gámiz, Fabiola"
Mostrando ítems 1-13 de 13
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Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero-Zerbo, Silvana Y.; [et al.] (2022-07)Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodríguez de Fonseca, Fernando; [et al.] (2021)Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Effects of sequential exposure to physical exercise and cognitive training on hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Mullor-Vigo, Rosa; Perez-Berlanga, José Manuel; Zambrana-Infantes, Emma; [et al.] (2022-07-13)AIMS: Physical exercise and cognitive training hippocampal dependent tasks are known to enhance adult hippocampal neurogenesis (AHN). Here we aimed to evaluate the effect of either a moderate-intensity exercise protocol, ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-10-01)Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
Mullor-Vigo, Rosa; Ávila-Gámiz, Fabiola; Zambrana-Infantes, Emma; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; [et al.] (2022)AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martin-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Y.; [et al.] (2022-07-20)Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil-Rodriguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; [et al.] (Elsevier, 2021)Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely ... -
Persistent drug-associated memories coexist with hippocampal-dependent cognitive decline and altered adult hippocampal neurogenesis in mice withdrawn from cocaine.
Mañas Padilla, María del Carmen; Gil-Rodriguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodríguez de Fonseca, Fernando; [et al.] (2019-10-01)Aims: Using a new animal model (‘chronic’ cocaine-induced conditioned place preference –CPP- paradigm), this work studied whether the long-term maintenance of cocaine-associated memories was concomitant to cognitive ... -
The presence of a social stimulus reduces cocaine seeking in a place preference conditioning paradigm.
Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Moreno-Fernández, Román D.; Santin-Nuñez, Luis Javier (2019-09-26)BACKGROUND: One challenge in the treatment of substance use disorders is to re-engage the interest toward non-drug-related activities. Among these activities, social interaction has had a prominent role due to its positive ... -
Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition
Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodríguez de Fonseca, Fernándo; [et al.] (Wiley, 2021)Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug seeking ... -
Spatial training in the Water Maze facilitates extinction and prevents reinstatement of cocaine-induced Conditioned Place Preference
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Zambrana-Infantes, Emma; Santin-Nuñez, Luis Javier; [et al.] (2021)Manipulation of adult hippocampal neurogenesis has been shown to affect the establishment of cocaine-context associations as well as extinction learning and reinstatement of these maladaptive memories. In this work, we ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
Sampedro-Piquero, Patricia; Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Santin-Nuñez, Luis Javier; [et al.] (Springer, 2019)The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ...