Listar por autor "Lucena Serrano, Cristina"
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Adsorbatos isoquinolínicos y benzazepínicos: síntesis e incorporación a superficies de silicio y nanopartículas
(UMA Editorial, 2019)La mayoría de los productos farmacéuticos aprobados por la FDA presentan en su estructura átomos de nitrógeno. De hecho, más de la mitad de ellos incluyen un heterociclo de nitrógeno. Entre los heterociclos de nitrógeno ... -
Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernández, María
; Lucena-Serrano, Cristina; Rivera-Ramírez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Shell-muscle attachment in the bivalves Ostrea stentina Payraudeau, 1826 and Anomia ephippium Linnaeus, 1758
Castro-Claros, Juan Diego; Salas-Casanova, María del Carmen; Lucena-Serrano, Cristina; Checa, Antonio (2019-10-07)
The muscles of the mantle in bivalves attach to the shell valves and retract the mantle edges. Among them, the adductors are particularly important for the survival of the animal. Most studies have addressed the type and ... -
SPION Nanoparticles for Delivery of Dopaminergic Isoquinoline and Benzazepine Derivatives.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; Villaverde, Gonzalo; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón; Laurenti, Marco; Rubio Retama, Jorge; Contreras-Cáceres, Rafael[et al.] (Elsevier, 2022-06-27)
Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with ... -
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Rivera-Ramírez, Alicia; López-Romero, Juan Manuel; Valpuesta-Fernández, María; Díaz-Morilla, Amelia[et al.] (Elsevier, 2018-07-05)
A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affinity and selectivity for ... -
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines
Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ... -
Synthesis of bioactive compounds. Studies of their attachment to nanoparticles
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ... -
The treatment of bacterial biofilms cultivated on knee arthroplasty implants using the bioelectric effect
Tamimi-Mariño, Iskandar Ahmad; Gasca, María; Halbardier, Alexandra; Martin, Sergio; Martin Caballero, Gregorio; Lucena Serrano, Cristina; Martin, Elena; Tamimi, Faleh; González-Quevedo, David; García-de-Quevedo-Puerta, David; Sobrino, Beatriz; Palop, Begoña; Guerado-Parra, Enrique; Pérez Lara, Almudena Ester; Urdiales, Cristina[et al.] (Frontiers, 2024-07-02)
Introduction: The formation of bacterial biofilms on knee arthroplasty implants can have catastrophic consequences. The aim of this study was to analyze the effectiveness of the bioelectric effect in the elimination of ...