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Listar por autor "Moreno García, Patricia"
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Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass
Moreno García, Patricia; Souto-Pereira, Sandra; Leiva Rebollo, Rocío; Bandín Matos, Isabel; Alonso-Sánchez, María del Carmen(Springer Nature, 2019-10-19)
European sea bass (Dicentrarchus labrax) is severely afected by nervous necrosis disease, caused by nervous necrosis virus (NNV). Two out of the four genotypes of this virus (red-spotted grouper nervous necrosis virus, ... -
Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells
Moreno-García, Patricia; Leiva-Rebollo, Rocío; García-Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
(Elsevier, 2022-08-23)
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a previous study, we developed ... -
Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E−11 cells
Moreno García, Patricia; Leiva Rebollo, Rocío; García Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
(Elsevier, 2022-08-18)
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a previous study, we developed ... -
Differential antiviral activity of Porphyridium cruentum polysaccharides against VHSV and NNV infections
Parra-Riofrio, Geovanna; Moreno-García, Patricia; Abdala-Díaz, Roberto Teófilo; García-Rosado, Esther
; Uribe-Tapia, Eduardo; Alonso-Sánchez, María del Carmen
; Béjar-Alvarado, Julia
[et al.] (2021-09)
The use of functional food can be an interesting approach to prevent viral diseases in aquaculture facilities. An increasing number of studies have suggested that marine microorganisms can be a relevant source of substances ... -
Estudio in vitro de la actividad tipo citoquina de ISG15 de lubina frente a infecciones por Betanodavirus
Moreno-García, Patricia; Leiva-Rebollo, Rocío; García-Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
(2022-09)
El sistema interferón tipo I (IFN-I) establece un estado antiviral mediante la transcripción de los llamados genes estimulados por IFN (ISG). Destaca el gen isg15, cuya proteína es la única descrita que presenta actividad ... -
European sea bass RTP3 genes: genomic characterization and transcription analyses.
Moreno-García, Patricia; Gémez-Mata, Juan; Álvarez-Torres, Daniel; García-Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
[et al.] (2023)
Introduction: Fish RTP3, belonging to receptor-transporting protein (RTP) family, has been described as an interferon-α (IFN-α)-responsive gene. However, little information is available about fish rtp3 gene structure and ... -
Evaluation of Gilthead Seabream (Sparus aurata) Immune Response after LCDV-Sa DNA Vaccination
Leiva Rebollo, Rocío; Castro-López, María Dolores; Moreno García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel (MDPI, 2021-05-29)
Lymphocystis disease is the main viral pathology in gilthead seabream aquaculture. Currently, there are no treatments or vaccines to control this disease, thus our main goal was to construct a DNA vaccine that can be used ... -
Evaluation of the immune response in betanodavirus-vaccinated gilthead seabream.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
An inactivated vaccine has been developed using a RGNNV/SJNNV reassortant strain isolated from Senegalese sole, which confers moderate protection against the homologous viral strain in sole juveniles. The aim of this study ... -
Genomic characterization and transcription analysis of European sea bass (Dicentrarchus labrax) rtp3 genes
Moreno-García, Patricia; Gémez-Mata, Juan; Álvarez-Torres, Daniel; García-Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
[et al.] (Elsevier, 2023-10-23)
Fish RTP3, belonging to the receptor-transporting protein family, display several functions, including a putative antiviral role as virus-responsive gene. In this work, we have identified and characterized two different ... -
Immune gene expression in gilthead seabream after nervous necrosis virus (NNV) challenge
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2022-09)
Viral nervous necrosis (VNN) is a disease that affects farmed fish worldwide. Its etiologic agent is the nervous necrosis virus (NNV), genus Betanodavirus, family Nodaviridae. NNV are small and non-enveloped viruses with ... -
Immune response of gilthead seabream infected with wild and mutant nervous necrosis virus reassortants.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2023)
Viral nervous necrosis (VNN) is a disease that affects farmed fish worldwide. Its etiologic agent is the nervous necrosis virus currently classified into 4 species: SJNNV, RGNNV, TPNNV and BFNNV. In Southern Europe, ... -
Immune response of Senegalese sole and gilthead seabream after vaccination with an inactivated vaccine against betanodavirus.
Gémez-Mata, Juan; Leiva-Rebollo, Rocío; Moreno-García, Patricia; Bandín Matos, Isabel; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; Castro-López, María Dolores[et al.] (2024)
Nervous necrosis virus (NNV) (genus Betanodavirus, family Nodaviridae) is the etiologic agent of viral encephalopathy and retinopathy (VER). This virus is classified into four species: SJNNV, RGNNV, TPNNV and BFNNV. In ... -
Setting out zebrafish (Danio rerio) as a model to study nervous necrosis virus-host interaction.
Moreno-García, Patricia; Álvarez-Torres, Daniel; Frétaud, Maxence; Mehraz, Manon; Langevin, Christelle; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen
[et al.] (2023)
Viral nervous necrosis is responsible for important economic losses in aquaculture facilities. The causative agent is the nervous necrosis virus (NNV). Four NNV species have been described, although only RGNNV and SJNNV ... -
Shewanella putrefaciens Pdp11 extracts promote European sea bass resistance against RGNNV infection.
Moreno-García, Patricia; Álvarez-Torres, Daniel; Gémez-Mata, Juan; Balebona-Accino, María del Carmen; Domínguez-Maqueda, Marta; Cerezo-Domínguez, Ana Isabel
; Moriñigo-Gutiérrez, Miguel Ángel
; Béjar-Alvarado, Julia
; García-Rosado, Esther
; Alonso-Sánchez, María del Carmen
[et al.] (2024)
The viral nervous necrosis (VNN) is a neurotropic disease affecting different fish species, resulting in high mortality rates. The causal agent is the nervous necrosis virus (NNV), belonging to the Betanodavirus genus, ... -
Shewanella putrefaciens Pdp11 extracts protect against betanodavirus infection.
Moreno-García, Patricia; Álvarez-Torres, Daniel; Balebona-Accino, María del Carmen; Moriñigo-Gutiérrez, Miguel Ángel
; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
; García-Rosado, Esther
[et al.] (2023)
Viral nervous necrosis is caused by the nervous necrosis virus (Betanodavirus genus), a naked virus with two positive-sense RNA segments. Betanodaviruses are classified into four species, being RGNNV predominant in the ... -
Understanding the role of European sea bass RTP3 protein in the course of betanodavirus infections.
Moreno-García, Patricia; Gémez-Mata, Juan; Álvarez-Torres, Daniel; García-Rosado, Esther; Béjar-Alvarado, Julia
; Alonso-Sánchez, María del Carmen
[et al.] (2024)
Nervous necrosis virus (NNV, Betanodavirus genus) is the causative agent of the viral nervous necrosis, the main viral disease affecting European sea bass. Betanodavirus genome is composed of two single-stranded, ...