Listar por autor "Forner, Stefania"
Mostrando ítems 1-16 de 16
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Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel
; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Núñez-Díaz, Cristina; Forner, Stefania; Martini, Alessandra C.; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Cadete Martini, Alessandra; Gomez-Arboledas, Angela; Forner, Stefania; Rodriguez-Ortiz, Carlos; McQuade, Amanda; Danhash, Emma; Phan, Jimmy; Javoncillo, Dominic; Ha, Jordan-Vu; Tram, Melanie; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Ager, Rahasson; Davila, Jose Carlos; Kitazawa, Masashi; Blurton-Jones, Mathew; Gutierrez, Antonia; Baglietto-Vargas, David; Medeiros, Rodrigo; LaFerla, Frank M[et al.] (National Academy of Sciences, 2019-10)
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the ... -
Astrocytes: From the physiology to the disease.
Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Forner, Stefania; Cadete Martini, Alessandra; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Betham Science, 2019)
Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many ... -
Dataset seeding paper JAL.
Andreo-López, Juana; Núñez-Díaz, Cristina; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Da Cunha, Celia; Cantero-Molina, Francisco; Campos-Moreno, Cynthia; Zimbone, Stefania; Bellia, Francesco; Giuffrida, Maria Laura; Trujillo-Estrada, Laura Isabel; García-León, Juan Antonio; Bettinetti-Luque, Miriam; Gámez, Nazaret; Valdés, Catalina; Morales, Rodrigo; Forner, Stefania; Martini, Alessandra C.; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (Universidad de Málaga, 2023-11-24)
Este trabajo se centra en el estudio de la propagación de la patología amiloidea en diferentes modelos animales para la Enfermedad de Alzheimer (EA). Los resultados sugieren que existen diversos factores que modulan este ... -
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
(Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Human amyloid seeds aggregate more efficient than seeds from old 3xtg-ad mice
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Tran, Janine Pham; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022)
Aims: Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice
Andreo-López, Juana; Núñez-Díaz, Cristina; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Da Cunha, Celia; Cantero-Molina, Francisco; Campos-Moreno, Cynthia; Zimbone, Stefania; Bellia, Francesco; Giuffrida, Maria Laura; Trujillo-Estrada, Laura Isabel; García-León, Juan Antonio; Bettinetti-Luque, Miriam; Gámez, Nazaret; Valdés, Catalina; Morales, Rodrigo; Forner, Stefania; Martini, Alessandra C.; Gutiérrez-Pérez, Antonia; LaFerla, Frank M.; Baglietto-Vargas, David[et al.] (Wiley, 2025-05-13)
Alzheimer's disease (AD) is a complex neurodegenerative proteinopathy in which Aβ and tau misfold and aggregate into entities that structurally unsettle native proteins, mimicking a prion-like or “seeding” process. These ... -
Human and mouse seeds differentially affect AB aggregation by modulating the inflammatory response.
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Morales-Cabello, Mario; Fatuarte Juli, Ivan; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2023)
Abstract text: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prionlike process. These amyloid aggregation ... -
Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2023)
Background: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. These amyloid aggregation ... -
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.
(Wiley, 2018-08-17)Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, ... -
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner, Stefania; Martini, Alessandra; Prieto, Gilberto Aleph; Dang, Cindy; Rodriguez-Ortiz, Carlos; Reyes Ruiz, Jorge Mauricio; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Andrews, Elizabeth; Phan, Jimmy; Ha, Jordan; Chang, Allissa; Levites, Yona; Cruz, Pedro; Ager, Rahasson; Medeiros, Rodrigo; Kitazawa, Masashi; Glabe, Charles; Cotman, Carl; Golde, Todd; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Springer Nature, 2019-11)
Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with ... -
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz, Carlos; Prieto, Gilberto Aleph; Martini, Alessandra; Forner, Stefania; Trujillo-Estrada, Laura Isabel; LaFerla, Frank M.; Baglietto-Vargas, David; Cotman, Carl; Kitazawa, Masashi[et al.] (Wiley, 2020-02-22)
MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation ofsynaptic functions. Among them, recent emerging evidence highlights that micro-RNA-181a (miR-181a) is particularly abundant in hippocampal ... -
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease
Trujillo-Estrada, Laura Isabel; Vanderklish, Peter; Minh Thu Nguyen, Marie; Kuang, Run Rong; Nguyen, Caroline; Huynh, Eric; da Cunha, Celia; Ibarra Javonillo, Dominic; Forner, Stefania; Martini, Alessandra C.; Sarraf, Stella; Simmon, Vicent; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Elsevier, 2021-10)
Alzheimer’s disease (AD) is conceptualized as a synaptic failure disorder in which loss of glutamatergic synapses is a major driver of cognitive decline. Thus, novel therapeutic strategies aimed at regenerating synapses ... -
Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.
Trujillo-Estrada, Laura Isabel; Nguyen, Cassidy; Da Cunha, Celia; Cai, Lena; Forner, Stefania; Martini, Alessandra C.; Ager, Rahasson; Prieto, Gilberto Aleph; Cotman, Carl; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Wiley, 2019-02-27)
Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on ... -
The effect of different amyloid seeds and animal hosts on amyloid propagation in Alzheimer's Disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Pham Tran, Janine; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Martini, Alessandra C.; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022-07-13)
Abstract text: Alzheimer's Disease is a neurodegenerative proteinopathy in which recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like ...