Listar por autor "Vegas-Gómez, Laura"
Mostrando ítems 1-9 de 9
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18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Cognitive decline and tau-associated pathology worsen after late-life depression in P301S mice.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia
; Moreno-González, Inés (2024)
Recent studies suggest that depression may be a crucial risk factor for the development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life depression and AD. ... -
Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Evaluation of neuroinflammation as modulator of tau aggregation in response to repetitive mild traumatic brain injury
(CSHL, 2022)The pathological misfolding and aggregation of hyper-phosphorylated tau (ptau) protein in neurofibrillary tangles (NFTs) is the main hallmark of a group of neurodegenerative diseases called tauopathies. These include ... -
Late-life depression accelerates cognitive decline in a tauopathy mouse model
Vegas-Gómez, Laura; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (IBRO/FENS, 2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Late-life depression accelerates cognitive impairment and tau-associated pathology in an Alzheimer´s disease model.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (CSHL, 2022)
Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ...