Listar por autor "Krejci, Pavel"

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Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.

Barad, Maya; Csukasi, Fabiana; Kunova-Bosakova, Michaela; Martin, Jorge H.; Zhang, Wenjuan; Taylor, Paige; Lachman, Ralph; Zieba, Jennifer; Bamshad, Michael; Nickerson, Deborah; Chong, Jessica X; Cohn, Daniel H; Krejci, Pavel; Krakow, Deborah; Duran, Ivan[et al.] (Elsevier, 2020-11-23)

Background Beyond its structural role in the skeleton, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ...
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling

Csukasi, Fabiana; Duran, Ivan; Barad, Maya; Barta, Tomas; Gudernova, Iva; Trantirek, Lukas; Martin, Jorge H; Kuo, Caroline Y; Woods, Jeremy; Lee, Hane; Cohn, Daniel H; Krejci, Pavel; Krakow, Deborah[et al.] (American Association for the Advancement of Science, 2018-09-19)

Studies have suggested a role for the mammalian (or mechanistic) target of rapamycin (mTOR) in skeletal development and homeostasis, yet there is no evidence connecting mTOR with the key signaling pathways that regulate ...