Listar por autor "Navarro, Victoria"
Mostrando ítems 1-20 de 20
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María
; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
Sanchez-Mico, Maria Virtudes; Jiménez, Sebastián; Gómez-Arboledas, Ángela; Muñoz-Castro, Clara; Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Galea, Elena; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Wiley, 2020-12-07)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Navarro, Victoria; Jiménez, Sebastián; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Navarro, Victoria; Gómez-Arboledas, Ángela; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres, Manuel; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Carmona, Irene; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2012-11-22)
Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in patients and transgenic models. These dystrophies could reflect the disruption of axonal transport ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Navarro, Victoria; Jiménez, Sebastián; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Romero-Molina, Carmen; Sánchez-Mejías, Elisabeth; Gómez-Arboledas, Ángela; Núñez-Díaz, Cristina; Navarro, Victoria; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-19)
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Fernández-Valenzuela, Juan José; Sanchez-Mico, Maria Virtudes; Muñoz-Castro, Clara; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Vizuete, Marisa[et al.] (Frontiers, 2018-11-14)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ... -
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Baglietto-Vargas, David; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2017)
Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2017-06-28)
Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jimenez, Sebastian; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2020-09-08)
In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ... -
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
March-Diaz, Rosana; Lara-Ureña, Nieves; Romero-Molina, Carmen; Heras-Garvin, Antonio; Ortega-de San Luis, Clara; Alvarez-Vergara, Maria I; Sanchez-Garcia, Manuel A; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Rosales-Nieves, Alicia E; Forja, Cristina; Navarro, Victoria; Gomez-Arboledas, Ángela; Sánchez-Mico, María Virtudes; Viehweger, Adrian; Gerpe, Almudena; Hodson, Emma J; Vizuete, Marisa; Bishop, Tammie; Serrano-Pozo, Alberto; Lopez-Barneo, Jose; Berra, Edurne; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Pascual, Alberto[et al.] (Nature Research, 2021-04)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD ... -
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada, Laura Isabel; Jiménez, Sebastián; De Castro, Vanessa; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; Navarro, Victoria; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2013)
Background: Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Muñoz-Castro, Clara; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2018-07-20)
Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Sánchez-Varo, Raquel María; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2019-07-17)
The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Moyano, F; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2016-10-14)
El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2021-03-09)
Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ...