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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Baglietto-Vargas, David; Forner, Stefania; Cai, Lena; Martini, Alessandra C; Trujillo-Estrada, Laura; Swarup, Vivek; Minh Thu Nguyen, Marie; Do Huynh, Kelly; Javonillo, Dominic I; Minh Tran, Kristine; Phan, Jimmy; Jiang, Shan; Kramár, Enikö A; Nuñez-Diaz, Cristina; Balderrama-Gutierrez, Gabriela; Garcia, Franklin; Childs, Jessica; Rodriguez-Ortiz, Carlos J; Garcia-Leon, Juan Antonio; Kitazawa, Masashi; Shahnawaz, Mohammad; Matheos, Dina P; Ma, Xinyi; Da Cunha, Celia; Walls, Ken C; Ager, Rahasson R; Soto, Claudio; Gutierrez, Antonia; Moreno-Gonzalez, Ines; Mortazavi, Ali; Tenner, Andrea J; MacGregor, Grant R; Wood, Marcelo; Green, Kim N; LaFerla, Frank M[et al.] (Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ...