Listar por autor "Concha-Marambio, Luis"

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The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

Park, Kyung-Won; Eun Kim, Gyoung; Morales, Rodrigo; Moda, Fabio; Moreno-González, Inés; Concha-Marambio, Luis; Lee, Amy S.; Hetz, Claudio; Soto, Claudio[et al.] (Springer Nature, 2017)

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic ...
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.

Diaz-Espinoza, R.; Morales, Rodrigo; Concha-Marambio, Luis; Moreno-González, Inés; Moda, Fabio; Soto, Claudio[et al.] (Springer Nature, 2018)

Transmissible spongiform encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP Sc) that self-propagates in the brain of infected individuals by converting ...