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Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
Matesanz, Fuencisla; Fedetz, María; Leyva-Fernández, Laura; Delgado, Concepción; Alcina, Antonio; Fernández-Fernández, Óscar[et al.] (Elsevier BV, 2004)The -330 IL2 gene promoter polymorphism has been associated with multiple sclerosis (MS) [J. Neuroimmunol. 119 (2001) 101], but the basis underlying this association remains unknown to date. In the present work, we have ... -
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
Alcina, Antonio; Fedetz, María; Ndagire, Dorothy; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Guerrero, Miguel; Abad-Grau, María del Mar; Arnal, Carmen; Delgado, Concepción; Lucas, Miguel; Izquierdo, Guillermo; Matesanz, Fuencisla[et al.] (Public Library of Science, 2009)Background:IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. Methods and Results: Here we perform a replication and ... -
The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
Matesanz, Fuencisla; Fernández-Fernández, Óscar; Milne, Roger L.; Fedetz, María; Leyva-Fernández, Laura; Guerrero, Miguel; Delgado, Concepción; Lucas, Miguel; Izquierdo, Guillermo; Alcina, Antonio[et al.] (Elsevier, 2008)Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three ...