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Listar por autor "González-Domínguez, Álvaro"
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Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
González-Domínguez, Álvaro; Belmonte, Thalía; Domínguez-Riscat, Jesús; Ruíz-Ocaña, Pablo; Muela-Zarzuela, Inés; Saez-Benito, Ana; Montañez, Raúl; Mateos, Rosa María; Lechuga-Sancho, Alfonso María[et al.] (Springer Nature, 2023-08-20)Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ... -
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria
González-Domínguez, Álvaro; Montañez, Raúl; Castejón-Vega, Beatriz; Nuñez-Vasco, Jéssica; Lendines-Cordero, Débora; Chun, Wang; Mbalaviele, Gabriel; Navarro-Pando, José M.; Alcocer-Gomez, Elísabet; Cordero, Mario[et al.] (EMBO press, 2021-10-07)Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome ...