• Metabolic changes upon GLS inhibition by CB-839 in glioma cell lines 

      Santos jiménez, Juan de los; Rosales, Tracy; Ko, Bookyung; Márquez-Gómez, Javier; Berardinis, Ralph J. de; [et al.] (2012-07-19)
      Many tumors use Gln for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. In ...
    • Metabolic impact of glutaminase isoenzymes modulation on glioma cell lines 

      de los Santos-Jiménez, Juan; Rosales, Tracy; Bookyung, Ko; Márquez-Gómez, Javier; DeBerardinis, Ralph J; [et al.] (2022)
      Many tumors use glutamine for both energy generation and as a biosynthetic precursor. Glutaminases (GAs) catalyze the first step of glutaminolysis by converting glutamine (Gln) into glutamate and ammonia in the mitochondria. ...