Listar por autor "Navarro, Juan Antonio"
Mostrando ítems 1-5 de 5
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D-chiro-inositol prevents memory deficits in the 3xTg mouse model of Alzheimer’s disease in a sex-dependent manner.
(2023)Alzheimer’s disease (AD) is recognized as an age-related neurodegenerative disorder, characterized by the aggregation and deposition of amyloid-β (Aβ) in plaques and neurofibrillary tangles (NFTs) composed of aggregates ... -
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
(WILEY, 2022-06-27)Background and Purpose Recent evidence links brain insulin resistance with neurodegenerative diseases, where hyperphosphorylated tau protein contributes to neuronal cell death. In the present study, we aimed to evaluate ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos
; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Endocrine and Metabolic impact of oral ingestion of a carob-pod derived natural syrup containing D-Pinitol: potential use as a novel sweetener in diabetes
Navarro, Juan Antonio; Decara, Juan; Dina, Medina; Tovar, Ruben; López-Gambero, Antonio J.; Pavón-Morón, Francisco Javier; Serrano, Antonia; De Ceglia, Marialuisa; Sanjuan, Carlos; Rodriguez-de-Fonseca, Fernando; Baixeras-Llano, Elena[et al.] (EMBO, 2022)
The use of added sugars or non-nutritive sweeteners in processed foods and soft drinks are being blamed for multiple complications associated with obesity and diabetes. High fructose content contributes to obesity and liver ... -
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Fernández-Arjona, María del Mar; Navarro, Juan Antonio; López-Gambero, Antonio J.; De Ceglia, Marialuisa; Rodríguez, Miguel; Rubio-Lamia, Leticia Olga; Rodríguez de Fonseca, Fernando; Barrios, Vicente; Chowen, Julie A.; Argente, Jesús; Rivera, Patricia; Suárez-Pérez, Juan[et al.] (BMC Springer Nature, 2024-04-08)
Understanding the physiological role of pregnancy-associated plasma protein-A2 (PAPP-A2), a proteinase involved in the insulin-like growth factor-1 (IGF1) availability to regulate growth, could provide insight into new ...