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Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
López-Gómez, Carlos; Pino-Ángeles, Almudena; Órpez-Zafra, Teresa; Pinto-Medel, Mª Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Arnáiz, Carlos; Guijarro-Castro, Cristina; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Sánchez-Jiménez, Francisca María
; Fernández Fernández, Oscar; Leyva-Fernández, Laura
[et al.] (Public Library of Sciences, 2013)
TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these genes in relation to ... -
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Alcina, Antonio; Fedetz, María; Fernández, Óscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva-Fernández, Laura; García-León, Juan Antonio
; Abad-Grau, María del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María Jesús; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla[et al.] (BMJ Journals, 2013-01)
Background and aim: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants ... -
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis
López-Gómez, Carlos; Fernández, Oscar; García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña
; Ortega-Pinazo, Jesús; Suardíaz-García, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Leyva-Fernández, Laura
[et al.] (Public Library of Science, 2011-07)
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce ...