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An extended reconstruction of human gut microbiota metabolism of dietary compounds.
Blasco, Telmo; Pérez-Burillo, Sergio; Balzerani, Francesco; Hinojosa Nogueira, Daniel; Lerma Aguilera, Alberto; Pastoriza, Silvia; Cendoya, Xabier; Rubio, Ángel; Gosalbes, María José; Jiménez Hernández, Nuria; Francino, María Pilar; Apaolaza, Íñigo; Rufián-Henares, José Ángel; Planes, Francisco Javier[et al.] (Springer Nature, 2021-08-05)Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to ... -
Cultivar and Harvest Time of Almonds Affect Their Antioxidant and Nutritional Profile through Gut Microbiota Modifications
Delgado-Osorio, Adriana; Navajas Porras, Beatriz; Pérez-Burillo, Sergio; Hinojosa-Nogueira, Daniel; Toledano-Marín, Ángela; Pastoriza, Silvia; Paliy, Oleg; Rufián-Henares, José Ángel[et al.] (MDPI, 2024-01-09)Almonds are a rich source of beneficial compounds for human health. In this work, we assessed the influence of almond cultivars and harvest time on their morphological (length, width and thickness) and nutritional (ash, ... -
Development of a food composition database of different food contaminants CONT11 and estimation of dietary exposure in children of southern Spain
Hinojosa-Nogueira, Daniel; Muros, José J.; Navajas Porras, Beatriz; Delgado-Osorio, Adriana; Pérez-Burillo, Sergio; Pastoriza, Silvia; Rufián-Henares, José Ángel[et al.] (Elsevier, 2023-05-26)Increasing food security is one of the Sustainable Development Goals. One of the main risks in food is the increase in food contaminants. Processing methods, such as the addition of additives or heat treatment, influence ... -
Effect of in vitro digestion and fermentation on antioxidant capacity of weight loss foods and Maillard reaction products content
Pérez-Burillo, Sergio; Hinojosa-Nogueira, Daniel; Rufián-Henares, José Ángel; Pastoriza, Silvia (Elsevier, 2023-02-27)Cereal snacks and meal replacement shakes are gaining popularity as part of a low-calorie diet. However, some concerns have been risen in relation to their nutrient content and industrial processing. Here we analyzed 74 ... -
Effect of roasting conditions on cocoa bioactivity and gut microbiota modulation.
Maldonado-Mateus, Lida Yaneth; Pérez-Burillo, Sergio; Lerma-Aguilera, Alberto; Hinojosa Nogueira, Daniel; Ruíz-Pérez, Sonia; Gosalbes, María José; Francino, Maria Pilar; Rufián-Henares, José Ángel; Pastoriza, Silvia[et al.] (Royal Society of Chemistry, 2021)Cocoa is a highly consumed food with beneficial effects on human health. Cocoa roasting has an important influence on its sensory and nutritional characteristics; therefore, roasting could also play a role in cocoa ... -
Evaluating the effects of a standardized polyphenol mixture extracted from poplar-type propolis on healthy and diseased human gut microbiota.
Garzarella, Emanuele Ugo; Navajas Porras, Beatriz; Pérez-Burillo, Sergio; Ullah, Hammad; Esposito, Cristina; Santarcangelo, Cristina; Hinojosa Nogueira, Daniel; Pastoriza, Silvia; Zaccaria, Vincenzo; Xiao, Jianbo; Rufián-Henares, José Ángel; Daglia, Maria[et al.] (Elsevier, 2022-04)Introduction: A large body of evidence suggests that propolis exerts antioxidant, anti-inflammatory, and antimicrobial activities, mostly ascribed to its polyphenol content. Growing evidence suggests that propolis ... -
Evaluation of Polyphenol Intake in Pregnant Women from South-Eastern Spain and the Effect on Anthropometric Measures at Birth and Gestational Age
Hinojosa-Nogueira, Daniel; Romero-Molina, Desirée; Gonzalez Alzaga, Beatriz; Giménez-Asensio, María José; Hernández, Antonio F.; Navajas Porras, Beatriz; Delgado-Osorio, Adriana; Gómez-Martín, Antonio; Pérez-Burillo, Sergio; Pastoriza, Silvia; Lacasaña, Marina; Rufián-Henares, José Ángel[et al.] (MDPI, 2024-09-13)During pregnancy, controlling nutrition is crucial for the health of both mother and foetus. While polyphenols have positive health effects, some studies show harmful outcomes during pregnancy. This study evaluated polyphenol ... -
In vitro batch fermentation protocol to study the contribution of food to gut microbiota composition and functionality
Pérez-Burillo, Sergio; Molino, Silvia; Navajas Porras, Beatriz; Valverde Moya, Álvaro; Hinojosa Nogueira, Daniel; López Maldonado, Alicia; Pastoriza, Silvia; Rufián-Henares, José Ángel[et al.] (Springer Nature, 2021)Knowledge about the effect of foods on gut microbiota composition and functionality is expanding. To isolate the effect of single foods and/or single nutrients (i.e. fibre, polyphenols), this protocol describes an in vitro ... -
Prediction of degradation pathways of phenolic compounds in the human gut microbiota through enzyme promiscuity methods.
Balzerani, Francesco; Hinojosa-Nogueira, Daniel; Cendoya, Xabier; Blasco, Telmo; Pérez-Burillo, Sergio; Apaolaza, Íñigo; Francino, María Pilar; Rufián-Henares, José Ángel; Planes, Francisco Javier[et al.] (Springer Nature, 2022)The relevance of phenolic compounds in the human diet has increased in recent years, particularly due to their role as natural antioxidants and chemopreventive agents in different diseases. In the human body, phenolic ... -
Relationship of Thermal Treatment and Antioxidant Capacity in Cooked Foods
Navajas Porras, Beatriz; Pérez-Burillo, Sergio; Hinojosa-Nogueira, Daniel; Pastoriza, Silvia; Rufián-Henares, José Ángel (MDPI, 2022-11-24)Most of the foods we eat undergo a cooking process before they are eaten. During such a process, the non-enzymatic browning occurs, which generates compounds such as furosine, 5-hydroxymethylfurfural (HMF) and furfural. ... -
Selenium bioaccesibility after in vitro digestion/fermentation of foods differs in adults and children.
García-Conde, Úrsula; Navarro-Alarcón, Miguel; Navajas Porras, Beatriz; Hinojosa-Nogueira, Daniel; Delgado-Osorio, Adriana; Navarro-Moreno, Miguel; Pérez-Burillo, Sergio; Pastoriza, Silvia; Douros, Konstantinos; Rufián-Henares, José Ángel[et al.] (Elsevier, 2024-03-25)Selenium (Se) as essential element regulates the immune, endocrine, reproductive and neurological systems through selenoproteins. More important than its content, is the fraction available to be absorbed (bioaccesibility) to ... -
Stance4Health Nutritional APP: A Path to Personalized Smart Nutrition
Hinojosa-Nogueira, Daniel; Ortiz-Viso, Bartolomé; Navajas Porras, Beatriz; Pérez-Burillo, Sergio; González-Vigil, Verónica; Pastoriza, Silvia; Rufián-Henares, José Ángel[et al.] (MDPI, 2023-01-05)Access to good nutritional health is one of the principal objectives of current society. Several e-services offer dietary advice. However, multifactorial and more individualized nutritional recommendations should be developed ... -
The Gut Microbiota of Obese Children Releases Lower Antioxidant Capacity from Food than That of Lean Children
Navajas Porras, Beatriz; Pérez-Burillo, Sergio; Hinojosa Nogueira, Daniel; Douros, Konstantinos; Pastoriza, Silvia; Rufián-Henares, José Ángel[et al.] (MDPI, 2022)The prevalence of obesity has been increasing in children over the last few decades, becoming a concern for health professionals and governments. Gut microbial community structure in obese people have been found to differ ... -
The Intake of Antioxidant Capacity of Children Depends on Their Health Status.
Navajas Porras, Beatriz; Pérez-Burillo, Sergio; Hinojosa-Nogueira, Daniel; Douros, Konstantinos; Pastoriza, Silvia; Rufián-Henares, José Ángel[et al.] (MDPI, 2022)The gastrointestinal digestion of food and further gut microbial activity render a myriad of different molecules that could be responsible for the biological activities that are classically assigned to their parent compounds. ... -
The Stance4Health Project: Evaluating a Smart Personalised Nutrition Service for Gut Microbiota Modulation in Normal-and Overweight Adults and Children with Obesity, Gluten-Related Disorders or Allergy/Intolerance to Cow’s Milk.
Dello Russo, Marika; Russo, Paola; Rufián-Henares, José Ángel; Hinojosa-Nogueira, Daniel; Pérez-Burillo, Sergio; Pastoriza de la Cueva, Silvia; Rohn, Sascha; Fatouros, Alexandra; Douros, Konstantinos; González-Vigil, Verónica; Epstein, David; Francino, María Pilar; Siani, Alfonso; Lauria, Fabio[et al.] (MDPI, 2022-05-19) -
Total Zn of foods and bioaccesible fractions in the small and large intestine after in vitro digestion and fermentation with fecal material of healthy adults and children: Influence of culinary techniques
García-Conde, Úrsula; Navarro-Alarcón, Miguel; Navajas Porras, Beatriz; Hinojosa-Nogueira, Daniel; Delgado-Osorio, Adriana; Pérez-Burillo, Sergio; Pastoriza, Silvia; Navarro-Moreno, Miguel; Rufián-Henares, José Ángel[et al.] (Elsevier, 2023-05-16)The healthy status of human beings is associated with an appropriate nutritional status in Zn, which must firstly be bioavailable. We measured the total Zn amount and its bioaccesibility in raw foods and after cooking by ...