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Capsid amino acids at positions 247 and 270 are involved in the virulence of betanodaviruses to European sea bass.
Moreno, Patricia; Souto, Sandra; Leiva-Rebollo, Rocío; Borrego-García, Juan José; Bandin, Isabel; Alonso-Sánchez, María del Carmen[et al.] (Nature Pubishing Group, 2019-10-01)
The role of the capsid protein (Cp) amino acids 247 and 270 in the virulence of a RGNNV isolate to sea bass (Dicentrarchus labrax) has been evaluated by the generation of recombinant RGNNV viruses harbouring SJNNV-type ... -
Differential immunogene expression profile of European sea bass (Dicentrarchus labrax, L.) in response to highly and low virulent NN
Moreno, Patricia; Gémez-Mata, Juan; García-Rosado, Esther; Béjar-Alvarado, Julia
; Labella Vera, Alejandro Manuel; Souto, Sandra; Alonso-Sánchez, María del Carmen
[et al.] (Elsevier, 2020)
European sea bass is highly susceptible to the nervous necrosis virus, RGNNV genotype, whereas natural outbreaks caused by the SJNNV genotype have not been recorded. The onset and severity of an infectious disease depend ... -
Immune Response of Senegalese Sole against Betanodavirus Mutants with Modified Virulence.
Gémez Mata, Juan; Souto, Sandra; Bandin, Isabel; Alonso-Sánchez, María del Carmen; Borrego-García, Juan José; Labella Vera, Alejandro Manuel; García-Rosado, Esther
[et al.] (MDPI, 2021-10-27)
Nervous necrosis virus (NNV), genus Betanodavirus, the etiological agent of the viral encephalopathy and retinopathy (VER), presents a genome with two positive-sense single-stranded RNA segments. Striped jack nervous ... -
Nervous Necrosis Virus (NNV) Booster Vaccination Increases Senegalese Sole Survival and Enhances Immunoprotection
López-Vázquez, Carmen; Souto, Sandra; Olveira, José G.; Riaza, Ana; González, Óscar; Labella Vera, Alejandro Manuel[et al.] (IOAP-MDPI, 2022-12-23)Viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV), is a serious threat to Senegalese sole farming. We have previously demonstrated that immunization with an inactivated vaccine confers ... -
Nervous necrosis virus (NNV) vaccination of carrier Senegalese sole (Solea senegalensis).
Souto, Sandra; Olveira, José; López-Vázquez, Carmen; Dopazo, Carlos; Labella Vera, Alejandro Manuel; Bandin, Isabel[et al.] (Elsevier, 2023)Viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV), is one of the most threatening diseases affecting marine farmed fish, especially in early developmental stages. In addition, subclinica ... -
RRGNNV capsid protein amino acids 247 and 270 are involved in betanodavirus virulence to European sea bass (Dicentrarchus labrax)
Moreno, Patricia; Souto, Sandra; Leiva-Rebollo, Rocío; García-Rosado, Esther; Borrego-García, Juan José; Bandín Matos, Isabel; Alonso-Sánchez, María del Carmen
[et al.] (2019-09-18)
Recombinant RGNNV viruses harbouring SJNNV-type amino acids at positions 247 and/or 270 (Mut247Dl965, Mut270Dl965, Mut247+270Dl965) were generated by reverse genetics. The effect of these modifications on viral replication ... -
Senegalese sole immune response against betanodavirus recombinants harboring modifications in the 3' terminal region of the RNA1
Gémez-Mata, Juan; Labella Vera, Alejandro Manuel; Souto, Sandra; Bandín Matos, Isabel; Borrego-García, Juan José; García-Rosado, Esther[et al.] (2021-09)
The nervous necrosis virus (NNV) is the etiological agent of the viral nervous necrosis (VNN), a disease affecting a high number of fish species worldwide. NNV genome is composed of two segments RNA1 and RNA2, encoding the ...