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Listar por autor "Csukasi, Fabiana"
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Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.
Barad, Maya; Csukasi, Fabiana; Kunova-Bosakova, Michaela; Martin, Jorge H.; Zhang, Wenjuan; Taylor, Paige; Lachman, Ralph; Zieba, Jennifer; Bamshad, Michael; Nickerson, Deborah; Chong, Jessica X; Cohn, Daniel H; Krejci, Pavel; Krakow, Deborah; Duran, Ivan[et al.] (Elsevier, 2020-11-23)Background Beyond its structural role in the skeleton, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Bone organoid generation based on double scaffolding.
Decellularized bone matrix ( is a classic approach in bone tissue engineering based on the removal of bone tissue cells and the calcified phase using chemical, physical o enzymatic agents The resulting matrix preserves ... -
Comprehensive Tissue-Specific Transcriptome Analysis Reveals Distinct Regulatory Programs during Early Tomato Fruit Development
Pattison, Richard J.; Csukasi, Fabiana; Zheng, Yi; Fei, Zhangjun; Catala, Carmen (Oxford Academy, 2015-06-22)Fruit formation and early development involve a range of physiological and morphological transformations of the various constituent tissues of the ovary. These developmental changes vary considerably according to tissue ... -
DEPTOR promotes bone marrow adipose tissue expansion in calorie restricted mice.
Elevated levels of fat in bones is a characteristic feature of osteoporosis and other skeletal disorders. While the molecular mechanism behind this shift between bone and fat formation remains incompletely understood, it ... -
Dominant-negative SOX9 mutations in campomelic dysplasia.
Csukasi, Fabiana; Duran, Ivan; Zhang, Wenjuan; Martin, Jorge H.; Barad, Maya; Bamshad, Michael; Weis, Mary Ann; Eyre, David; Krakow, Deborah; Cohn, Daniel H.[et al.] (Wiley, 2019-08-07)Campomelic dysplasia (CD) is an autosomal dominant, perinatal lethal skeletaldysplasia characterized by a small chest and short long bones with bowing of thelower extremities. CD is the result of heterozygosity for mutations ... -
Generation and analysis of ESTs from strawberry (Fragaria xananassa) fruits and evaluation of their utility in genetic and molecular studies
Bombarely, Aureliano; Merchante-Berg, Catharina; Csukasi, Fabiana; Cruz-Rus, Eduardo; Caballero, José L.; Medina-Escobar, Nieves; Blanco-Portales, Rosario; Botella, Miguel A.; Muñoz-Blanco, Juan; Sánchez-Sevilla, José F; Valpuesta-Fernández, Victoriano[et al.] (BMC, 2010-09-17)
Cultivated strawberry is a octoploid species whose fruit is highly appreciated due to its organoleptic properties and health benefits. However, information about the role played by different hormones on these processes ... -
Gibberellin biosynthesis and signalling during development of the strawberry receptacle
Csukasi, Fabiana; Osorio-Algar, Sonia; Gutiérrez, José R.; Kitamura, Jun; Giavalisco, Patrick; Nakajima, Masatoshi; Fernie, Alisdair R.; Rathjen, John R.; Botella-Mesa, Miguel Ángel
; Valpuesta-Fernández, Victoriano
; Medina-Escobar, Nieves[et al.] (Wiley, 2011-07-19)
Essential factors controlling the growth and development of strawberry (Fragaria × ananassa) fruit are poorly characterized at the molecular level. The roles played by different hormones in these processes remain largely ... -
Mechanisms regulating auxin action during fruit development
Pattison, Richard J.; Csukasi, Fabiana; Catala, Carmen (Wiley Online Library, 2013-12-16)Auxin controls many aspects of fruit development, including fruit set and growth, ripening and abscission. However, the mechanisms by which auxin regulates these processes are still poorly understood. While it is generally ... -
Modification of plant hormone levels and signaling as a tool in plant biotechnology.
Csukasi, Fabiana; Merchante-Berg, Catharina; Valpuesta-Fernández, Victoriano(Wiley, 2009-09-23)
Plant hormones are signal molecules, present in trace quantities, that act as major regulators of plant growth and development. They are involved in a wide range of processes such as elongation, flowering, root formation ... -
Mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia
Barad, M.; Csukasi, Fabiana; Krakow, D.; Durán-Jimenez, Iván Jesús(2020-09-24)
In addition to its structural role in skeletogenesis, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR
Csukasi, Fabiana (2022)Alterations in the balance between skeletogenesis and adipogenesis is a pathogenic feature in multiple skeletal disorders. Clinically, enhanced bone marrow adiposity in bones impairs mobility and increases fracture risk, ... -
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
Csukasi, Fabiana; Duran, Ivan; Barad, Maya; Barta, Tomas; Gudernova, Iva; Trantirek, Lukas; Martin, Jorge H; Kuo, Caroline Y; Woods, Jeremy; Lee, Hane; Cohn, Daniel H; Krejci, Pavel; Krakow, Deborah[et al.] (American Association for the Advancement of Science, 2018-09-19)Studies have suggested a role for the mammalian (or mechanistic) target of rapamycin (mTOR) in skeletal development and homeostasis, yet there is no evidence connecting mTOR with the key signaling pathways that regulate ... -
The Skeletal Atlas: A holistic approach to transcriptomics in the skeleton.
Pérez-Tejeiro, José Miguel; Csukasi, Fabiana; Becerra-Ratia, José; Durán-Jimenez, Iván Jesús
; Fernández-Pozo, Noé (2023)
Gene expression atlases are powerful bioinformatics tools that allow access to the scientific community to explore omics data. In biomedicine, numerous gene expression databases are available, yet none provide enough ... -
Transcriptomic Analysis in Strawberry Fruits Reveals Active Auxin Biosynthesis and Signaling in the Ripe Receptacle.
Estrada Johnson, Elizabeth; Csukasi, Fabiana; Martín-Pizarro, Carmen; Vallarino, José G.; Kiryakova, Yulia; Vioque, Amalia; Brumós, Javier; Medina-Escobar, Nieves; Botella-Mesa, Miguel Ángel; Alonso, José M.; Fernie, Alisdair R.; Sánchez-Sevilla, José F.; Osorio-Algar, Sonia
; Valpuesta-Fernández, Victoriano
[et al.] (Frontiers, 2017-05-29)
The role of auxin in ripening strawberry (Fragaria ×ananassa) fruits has been restricted to the early stages of development where the growth of the receptacle is dependent on the delivery of auxin from the achenes. At later ... -
Two strawberry miR159 family members display developmental specific expression patterns in the fruit receptacle and cooperatively regulate Fa-GAMYB
Csukasi, Fabiana; Donaire, Livia; Casañal Seoane, Ana; Martínez-Priego, Llúcia; Botella-Mesa, Miguel Ángel; Medina-Escobar, Nieves; Llave, César; Valpuesta-Fernández, Victoriano
[et al.] (Wiley, 2012-02-26)
We have reported previously that the gibberellin (GA) content in strawberry receptacle is high, peaking at specific stages, pointing to a role of this hormone in fruit development. In Arabidopsis, miR159 levels are dependent ...