
- RIUMA Principal
- Listar por autor
Listar por autor "Cheng-Sánchez, Iván"
Mostrando ítems 1-20 de 22
-
An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Guerrero Vásquez, Guillermo A.; Sarabia-García, Francisco Ramón(ACS, 2017)
A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, ... -
An olefin metathesis approach towards the solomonamides.
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Sarabia-García, Francisco Ramón(Elsevier, 2016)
A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel
; Sarabia-García, Francisco Ramón
; Rodríguez-Quesada, Ana María
[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Bengamide Analogues Show a Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
García-Pinel, Beatriz; Porras Alcalá, Cristina; Cabeza, Laura; Ortiz, Raul; Prados, José; Melguizo, Consolación; Cheng-Sánchez, Iván; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón
[et al.] (2020-05-02)
The limited success and side effects of the current chemotherapeutic strategies against colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs. The prominent antitumor activities ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel
; Sarabia-García, Francisco Ramón
; García-Caballero, Melissa; Rodríguez-Quesada, Ana María
[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes
Du, Xiaoyong; Cheng-Sánchez, Iván; Nevado, Cristina (ACS, 2023-05-30)An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C–C and a C–S bond across the π-system, uses a dual nickel/photoredox catalytic system ... -
Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and In Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis
Carrillo, Paloma; Martínez-Póveda, Beatriz Amparo; Cheng-Sánchez, Iván; Guerra, Jessica; Tobia, Chiara; López-Romero, Juan Manuel
; Sarabia-García, Francisco Ramón
; Medina-Torres, Miguel Ángel
; Rodríguez-Quesada, Ana María
[et al.] (2019-04-15)
Marine sponges are a prolific source of bioactive compounds. In this work, the putative antiangiogenic potential of a series of synthetic precursors of Solomonamide A, a cyclic peptide isolated from a marine sponge, was ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel
; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María
; López-Romero, Juan Manuel
; Sarabia-García, Francisco Ramón
[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers
Dolbois, Aymeric; Batiste, Laurent; Wiedmer, Lars; Dong, Jing; Brütsch, Manuela; Huang, Danzhi; Deerain, Nicholas M.; Spiliotopoulos, Dimitrios; Cheng-Sánchez, Iván; Laul, Eleen; Nevado, Cristina; Śledź, Paweł; Caflisch, Amedeo[et al.] (ACS Publications, 2020-06-30)Small molecule ligand binding to the ATAD2 bromodomain is investigated here through the synergistic combination of molecular dynamics and protein crystallography. A previously unexplored conformation of the binding pocket ... -
Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides
Hu, Xia; Cheng-Sánchez, Iván; Cuesta-Galisteo, Sergio; Nevado, Cristina (ACS, 2023-03-07)An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl homoallylic amines with excellent ... -
An Olefin Metathesis-Based Strategy for the Synthesis of New Antitumoral Compounds Inspired by Natural Products
Cheng-Sánchez, Iván (UMA Editorial, 2019)his PhD Thesis proposes the discovery and development of new drugs inspired by bioactive natural products, which represent valid platforms for the generation of new chemical entities of pharmaceutical interest. In particular, ... -
Stereoselective total synthesis of (-)-Depudecin
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing ... -
Synthesis and Antitumor Activity Evaluation of Compounds Based on Toluquinol
Cheng-Sánchez, Iván; Torres-Vargas, José Antonio; Martínez-Póveda, Beatriz Amparo; Guerrero Vásquez, Guillermo A.; Medina, Miguel Ángel; Sarabia-García, Francisco Ramón
; Quesada, Ana R.[et al.] (MDPI, 2019-08-23)
Encouraged by the promising antitumoral, antiangiogenic, and antilymphangiogenic properties of toluquinol, a set of analogues of this natural product of marine origin was synthesized to explore and evaluate the effects of ... -
Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides
Cheng-Sánchez, Iván; Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel
; Sarabia-García, Francisco Ramón
[et al.] (2018-10-15)
Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ... -
Synthesis and Biological Evaluation of Depudecin Analogues
Cheng-Sánchez, Iván; Carrillo Fernández, Paloma; García-Ruiz, Cristina; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel
; Sarabia-García, Francisco Ramón
[et al.] (2019-09-18)
(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ... -
Synthesis of (-)- and (+)-Gummiferol via Asymmetric Synthesis of Glycidic Amides.
García-Ruiz, Cristina; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón(Thieme, 2016)
An efficient synthesis of the natural product (–)-gummiferol is achieved according to a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts. This new methodology allows the rapid ... -
Synthesis of (-)-cannabidiol (CBD),(-)-Δ9- and(-)--Δ8-tetrahydrocannabinols, encapsulation of CBD with nanoparticles for controlled delivery and biological evaluation
Moya-Utrera, Federico; Fuentes-Ríos, David; Romero-Carrasco, Antonio; Doña Flores, Manuel; Cheng-Sánchez, Iván; Díaz-Morilla, Amelia; Pino-González, María Soledad
; Martínez-Férez, Antonio; Moreno, Javier; Mesas, Cristina; Melguizo, Consolación; Prados, José; Sarabia-García, Francisco Ramón
; López-Romero, Juan Manuel
[et al.] (Wiley, 2024-12)
Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD ... -
Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes
Aguera-Suárez, Ana María; Porras Alcalá, Cristina; Guerrero Vásquez, Guillermo A.; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón(2017-07-20)
Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. ... -
Synthesis of the Macrocylic Core of the Solomonamides, a New Class of Cyclopeptides of Marine Origin
Cheng-Sánchez, Iván (2016-09-29)Se describe estudios sintéticos dirigidos hacia la síntesis total de solomonamides, una nueva clase de ciclopéptidos de origen marino que presentan interesantes propiedades biológicas. La aproximación sintética se basó en ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; Pino-González, María Soledad
; Díaz-Morilla, Amelia
; Kitamura, Seiya; W. Wolan, Dennis; Prados, Jose; Melguizo, Consolación; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón
[et al.] (IOAP-MPDI, 2022-05-31)
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ...