
- RIUMA Principal
- Listar por autor
Listar por autor "Cheng-Sánchez, Iván"
Mostrando ítems 1-9 de 9
-
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel
; Sarabia-Garcia, Francisco Ramon
; Rodriguez-Quesada, Ana Maria
[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel
; Carrillo Fernández, Paloma; Rodriguez-Quesada, Ana Maria
; López-Romero, Juan Manuel
; Sarabia-Garcia, Francisco Ramon
[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
An Olefin Metathesis-Based Strategy for the Synthesis of New Antitumoral Compounds Inspired by Natural Products
Cheng-Sánchez, Iván (UMA Editorial, 2019)his PhD Thesis proposes the discovery and development of new drugs inspired by bioactive natural products, which represent valid platforms for the generation of new chemical entities of pharmaceutical interest. In particular, ... -
Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides
Cheng-Sánchez, Iván; Carrillo Fernández, Paloma; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria
; Medina, Miguel Ángel
; Sarabia-Garcia, Francisco Ramon
[et al.] (2018-10-15)
Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ... -
Synthesis and Biological Evaluation of Depudecin Analogues
Cheng-Sánchez, Iván; Carrillo Fernández, Paloma; Garcia-Ruiz, Maria Cristina; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria
; Medina, Miguel Ángel
; Sarabia-Garcia, Francisco Ramon
[et al.] (2019-09-18)
(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ... -
Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes
Aguera-Suárez, Ana María; Porras Alcalá, Cristina; Guerreo Vásquez, Guillermo A.; Cheng-Sánchez, Iván; Sarabia-Garcia, Francisco Ramon(2017-07-20)
Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. ... -
Synthesis of the Macrocylic Core of the Solomonamides, a New Class of Cyclopeptides of Marine Origin
Cheng-Sánchez, Iván (2016-09-29)Se describe estudios sintéticos dirigidos hacia la síntesis total de solomonamides, una nueva clase de ciclopéptidos de origen marino que presentan interesantes propiedades biológicas. La aproximación sintética se basó en ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; Pino-Gonzalez, Maria Soledad
; Díaz-Morilla, Amelia
; Kitamura, Seiya; W. Wolan, Dennis; Prados, Jose; Melguizo, Consolación; Cheng-Sánchez, Iván; Sarabia-Garcia, Francisco Ramon
[et al.] (IOAP-MPDI, 2022-05-31)
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ... -
Total synthesis of depudecin and analogues via an olefin cross-metathesis based strategy
Cheng-Sánchez, Iván; Sarabia-Garcia, Francisco Ramon(2017-07-20)
(-)-Depudecin (1), isolated from the culture broths of the fungus Alternaria brassicicola [1], has been identified as a selective inhibitor of histone deacetylases (HDAC) with an IC50 in the low μM range. In contrast to ...