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Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old
Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Sanabria-Cabrera, Judith Adriana
; Robles-Díaz, María Mercedes
; Ortega-Alonso, Aida; García-Cortés, Miren
; Bonilla, Elvira; Niu, Hao; Soriano, German; Jiménez-Pérez, Miguel
; Hallal, Hacibe; Blanco, Sonia; Kaplowitz, Neil; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
[et al.] (Wiley, 2020-11-11)
Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ... -
Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries
García-Cortés, Miren; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, Inmaculada
; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María Isabel
; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes
; Andrade-Bellido, Raúl Jesús
[et al.] (Wiley, 2023)
Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), ... -
Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry
Stephens, Camilla; Robles-Díaz, María Mercedes; Medina-Cáliz, Inmaculada
; García-Cortés, Miren
; Ortega-Alonso, Aida; Sanabria-Cabrera, Judith Adriana
; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Slim, Mahmoud; Jiménez-Pérez, Miguel
; González-Grande, Rocío; Fernández, M. Carmen; Casado, Marta; Soriano, German; Roman, Eva; Hallal, Hacibe; Romero-Gomez, Manuel; Castiella, Agustin; Conde, Isabel; Prieto, Martin; Moreno-Planas, José María; Giraldez, Alvaro; Moreno-Sanfiel, J Miguel; Kaplowitz, Neil; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
[et al.] (Elsevier, 2021-02-01)
Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ... -
Drug-Induced Liver Injury in Latin America: 10-year experience of the Latin American DILI (LATINDILI) Network
Bessone, Fernando; Hernandez, Nelia; Medina-Caliz, Inmaculada; García-Cortés, Miren; Schinoni, María I.; Mendizabal, Manuel; Chiodi, Daniela; Nunes, Vinicius; Ridruejo, Ezequiel; Pazos, Ximena; Santos, Genario; Fassio, Eduardo; Parana, Raymundo; Reggiardo, Virginia; Tanno, Hugo; Sanchez, Adriana; Tanno, Federico; Montes, Pedro; Tagle, Martin; Arrese, Marco; Brahm, Javier; Girala, Marcos; Lizarzabal, M. Isabel; Carrera, Enrique; Zerega, Alina; Bianchi, Carla; Reyes, Laura; Arnedillo, Daina; Cordone, Antonella; Gualano, Gisela; Jaureguizahar, Fernanda; Rifrani, Gabriel; Robles‑Diaz, Mercedes; Ortega-Alonso, Aida; Pinazo-Bandera, Jose M.; Stephens, Camilla; Sanabria-Cabrera, Judith
; Bonilla-Toyos, Elvira; Niu, Hao; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade, Raúl J.[et al.] (Elsevier, 2024-07)
Background and aims: Latin America is a region of great interest for studying the clinical presentation of idiosyncratic drug-induced liver injury (DILI). A comprehensive analysis of patients enrolled into the LATINDILI ... -
Estudio de los fenómenos de autoinmunidad en la enfermedad hepática tóxica
Ortega-Alonso, Aida (UMA Editorial, 2017)La hepatotoxicidad idiosincrásica (DILI) por xenobióticos (fármacos, hierbas o productos de herboristería) es probablemente una de las enfermedades hepáticas más desconcertante y compleja, con múltiples facetas y gran ... -
Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage
Cueto-Sánchez, Alejandro; Niu, Hao; Alvarez-Alvarez, Ismael; López-Longarela, Bárbara; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; García-Cortés, Miren; Pinazo-Bandera, José M.; Sanabria-Cabrera, Judith Adriana
; Díaz-Monchón, Juan José; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
; Stephens, Camilla; Robles-Díaz, María Mercedes
[et al.] (Wiley, 2023)
Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis ... -
Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
Medina-Cáliz, Inmaculada; García-Cortés, Miren
; González-Jiménez, Andrés; Cabello-Porras, María Rosario
; Robles-Díaz, María Mercedes
; Sanabria-Cabrera, Judith Adriana
; Sanjuan-Jimenez, Rocio; Ortega-Alonso, Aida; García-Muñoz, Beatriz; Moreno, Inmaculada; Jiménez-Pérez, Miguel
; Fernández, M. Carmen; Ginés, Pere; Prieto, Martin; Conde, Isabel; Hallal, Hacibe; Soriano, German; Roman, Eva; Castiella, Agustin; Blanco-Reina, Encarnación
; Montes, Maria R; Quiros-Cano, Marta; Martín-Reyes, Flores; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
[et al.] (Elsevier, 2018-01)
There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients ... -
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Sanabria-Cabrera, Judith Adriana; Sanjuan-Jimenez, Rocio; Clavijo-Frutos, Encarnación
; Medina-Cáliz, Inmaculada
; González-Jiménez, Andrés; García-Cortés, Miren
; Ortega-Alonso, Aida; Jiménez-Pérez, Miguel
; González-Grande, Rocío; Stephens, Camilla; Robles-Díaz, María Mercedes
; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
[et al.] (2020)
Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ... -
Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study
Cueto-Sánchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Díaz, María Mercedes; Sanabria-Cabrera, Judith Adriana
; Ortega-Alonso, Aida; García-Cortés, Miren
; González-Grande, Rocío; Jiménez-Pérez, Miguel
; Ruiz-Cabello, Francisco; Andrade-Bellido, Raúl Jesús
; Lucena-González, María Isabel
[et al.] (Wiley, 2021-09-20)
The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ... -
Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury
Rodriguez-Diaz, Cristina; Taminiau, Bernard; García-García, Alberto; Cueto-Sánchez, Alejandro; Robles-Díaz, María Mercedes; Ortega-Alonso, Aida; Martín-Reyes, Flores; Daube, Georges; Sanabria-Cabrera, Judith Adriana
; Jiménez-Pérez, Miguel
; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
; García Fuentes, Eduardo; García-Cortés, Miren
[et al.] (Elsevier, 2022-08)
The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders ... -
Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification
Niu, Hao; Solis-Muñoz, Pablo; García-Cortés, Miren; Sanabria-Cabrera, Judith Adriana
; Robles-Díaz, María Mercedes
; Romero-Flores, Rocío; Bonilla-Toyos, Elvira; Ortega-Alonso, Aida; Pinazo-Bandera, José M.; Cabello-Porras, María Rosario
; Bessone, Fernando; Hernandez, Nelia; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
; Medina-Cáliz, Inmaculada
; Alvarez-Alvarez, Ismael[et al.] (Elsevier, 2023-12-08)
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and ... -
Rechallenge in idiosyncratic drug-induced liver injury: An analysis of cases in two large prospective registries according to existing definitions
Pinazo-Bandera, José M.; Niu, Hao; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Del Campo-Herrera, Enrique; Ortega-Alonso, Aida; Robles-Díaz, María Mercedes
; Hernandez, Nelia; Parana, Raymundo; Nunes, Vinicius; Girala, M.; Bessone, Fernando; Lucena-González, María Isabel
; Andrade-Bellido, Raúl Jesús
; García-Cortés, Miren
[et al.] (Elsevier, 2024-05)
Los datos sobre la reexposición positiva en la lesión hepática inducida por fármacos (DILI) idiosincrásica son escasos. Apuntamos a analizar la presentación clínica, el resultado y los fármacos asociados con la reexposición ...