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Differential transcriptional response to antibiotics by Pseudomonas putida DOT-T1E
Molina-Santiago, Carlos; Daddaoua, Abdelali; Gómez-Lozano, María; Udaondo, Zulema; Molin, Soren; Ramos, Juan-Luis[et al.] (Wiley, 2015)Multi-drug resistant bacteria are a major threat to humanity, especially because the current battery of known antibiotics is not sufficient to combat infections produced by these microbes. Therefore, the study of how current ... -
Draft whole-genome sequence of the antibiotic-producing soil isolate Pseudomonas sp. strain 250J
Molina-Santiago, Carlos; Udaondo, Zulema; Ramos, Juan-Luis (Wiley, 2014)Bacteria of the genus Pseudomonas are becoming increasing well known for their ability to produce a wide range of antimicrobial compounds. In a largescale screening for antibiotic producers, we identified a soil isolate ... -
Efflux pump-deficient mutants as a platform to search for microbes that produce antibiotics
Molina-Santiago, Carlos; Udaondo, Zulema; Daddaoua, Abdelali; Roca, Amalia; Martín, Jesús; Pérez-Victoria, Ignacio; Reyes, Fernando; Ramos, Juan Luis[et al.] (Wiley, 2015-01-08)Pseudomonas putida DOT-T1E-18 is a strain deficient in the major antibiotic efflux pump (TtgABC) that exhibits an overall increased susceptibility to a wide range of drugs when compared with the wild-type strain. We used ... -
Full Transcriptomic Response of Pseudomonas aeruginosa to an Inulin-Derived Fructooligosaccharide.
Rubio-Gómez, José Manuel; Molina-Santiago, Carlos; Udaondo, Zulema; Tena Garitaonaindia, Mireia; Krell, Tino; Ramos, Juan Luis; Daddaoua, Abdelali[et al.] (Frontiers, 2020-02-20)Pseudomonas aeruginosa is an ubiquitous gram-negative opportunistic human pathogen which is not considered part of the human commensal gut microbiota. However, depletion of the intestinal microbiota (Dysbiosis) following ... -
Global transcriptional response of solvent‐sensitive and solvent‐tolerant Pseudomonas putida strains exposed to toluene.
Molina-Santiago, Carlos; Udaondo, Zulema; Gómez-Lozano, María; Molin, Soren; Ramos, Juan Luis (Wiley, 2016)Pseudomonas putida strains are generally recognized as solvent tolerant, exhibiting varied sensitivity to organic solvents. Pan-genome analysis has revealed that 30% of genes belong to the core-genome of Pseudomonas. ...