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Listar por autor "Montañez, Raúl"
Mostrando ítems 1-20 de 20
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A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco
(Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
A morphospace for synthetic organs and organoids: the possible and the actual.
(Oxford University Press, 2016)Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with ... -
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
(Springer Nature, 2023-08-20)Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ... -
AMMO-Prot: Amine system project 3D-model finder
Navas-Delgado, Ismael; Pino-Ángeles, Almudena; Montañez, Raúl; Moya-García, Aurelio Ángel; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Aldana-Montes, José Francisco[et al.] (Springer Nature, 2008-04)
Background: Amines are biogenic amino acid derivatives, which play pleiotropic and very important yet complex roles in animal physiology. For many other relevant biomolecules, biochemical and molecular data are being ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, José Luis; Medina-Torres, Miguel Ángel; Montañez, Raúl (2017-08-29)
It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Coexistence of nestedness and modularity in host–pathogen infection networks.
(Springer Nature, 2020)The long-term coevolution of hosts and pathogens in their environment forms a complex web of multi-scale interactions. Understanding how environmental heterogeneity affects the structure of host–pathogen networks is a ... -
Dealing with the genetic load in bacterial synthetic biology circuits: convergences with the Ohm's law.
Carbonell-Ballesteros, Max; García-Ramallo, Eva; Montañez, Raúl; Rodríguez-Caso, Carlos Francisco; Macía, Javier (2015)
Synthetic biology seeks to envision living cells as a matter of engineering. However, increasing evidence suggests that the genetic load imposed by the incorporation of synthetic devices in a living organism introduces a ... -
Emergence of proto-organisms from bistable stochastic differentiation and adhesion.
(The Royal Society, 2016-04-13)The rise of multicellularity in the early evolution of life represents a major challenge for evolutionary biology. Guidance for finding answers has emerged from disparate fields, from phylogenetics to modelling and synthetic ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Carrillo Fernández, Paloma; Urdiales-Ruiz, José Luis; Serrano, José J.; Montañez, Raúl; Rodríguez-Quesada, Ana María[et al.] (2017-08-29)
The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Exploring and challenging the network of angiogenesis
Montañez, Raúl; Sánchez-Jiménez, Francisca María; Medina, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer Nature, 2011-08-11)
Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a ... -
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria
(EMBO press, 2021-10-07)Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome ... -
Mathematical Modeling of Polyamine Metabolism in Mammals.
Rodríguez-Caso, Carlos Francisco; Montañez, Raúl; Cascante, Marta; Sánchez-Jiménez, Francisca María; Medina-Torres, Miguel Ángel (Elsevier, 2006)
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, ... -
MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway.
Fernández-Lozano, Jesús; Montañez, Raúl; Bellés, Xavier (National Academy of Sciences, 2015)
In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process ... -
Population dynamics of synthetic terraformation motifs.
(The Royal Society, 2018-07-04)Ecosystems are complex systems, currently experiencing several threats associated with global warming, intensive exploitation and human-driven habitat degradation. Because of a general presence of multiple stable states, ... -
Spatial dynamics of synthetic microbial mutualists and their parasites.
(PLOS, 2017-08-21)A major force contributing to the emergence of novelty in nature is the presence of cooperative interactions, where two or more components of a system act in synergy, sometimes leading to higher-order, emergent phenomena. ... -
Spatial self-organization in hybrid models of multicellular adhesion.
(American Institute of Physics, 2016-10-26)Spatial self-organization emerges in distributed systems exhibiting local interactions when nonlinearities and the appropriate propagation of signals are at work. These kinds of phenomena can be modeled with different ... -
Synthetic circuit designs for earth terraformation
(Springer Nature, 2015-07-18)Background: Mounting evidence indicates that our planet might experience runaway effects associated to rising temperatures and ecosystem overexploitation, leading to catastrophic shifts on short time scales. Remediation ... -
Synthetic collective intelligence.
(Elsevier, 2016)Intelligent systems have emerged in our biosphere in different contexts and achieving different levels of complexity. The requirement of communication in a social context has been in all cases a determinant. The human ... -
VUS next in rare diseases? Deciphering genetic determinants of biomolecular condensation
(BioMed Central, 2024-09-06)The diagnostic odysseys for rare disease patients are getting shorter as next-generation sequencing becomes more widespread. However, the complex genetic diversity and factors influencing expressivity continue to challenge ... -
When metabolism meets topology: Reconciling metabolite and reaction networks.
Montañez, Raúl; Medina-Torres, Miguel Ángel; Solé, Ricard V.; Rodríguez-Caso, Carlos Francisco (Wiley, 2010)
The search for a systems-level picture of metabolism as a web of molecular interactions provides a paradigmatic example of how the methods used to characterize a system can bias the interpretation of its functional meaning. ...