Listar por autor "Macias-Gonzalez, Manuel"
Mostrando ítems 1-12 de 12
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8-oxoguanine DNA glycosylase 1 upregulation as a risk factor for obesity and colorectal cancer
Pilo, Jesús; García-Flores, Libia Alejandra; Clemente-Postigo, María Mercedes
; Arranz-Salas, Isabel María; Alcaide, Julia; Ramos-Fernandez, Maria; Lozano-Castro, José; Boughanem Lakhal, Hatim; Kompella, Pallavi; Macías-González, Manuel[et al.] (MDPI, 2023-03-13)
DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of ... -
Adipose tissue inflammation and VDR expression and methylation in colorectal cancer
Castellano-Castillo, Daniel; Morcillo Espina, Sonsoles; Clemente-Postigo, María Mercedes; Crujeiras Martínez, Ana Belén; Fernández-García, José Carlos; Torres Sánchez, Esperanza; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (BMC (Part of Springer Nature), 2018)
Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. ... -
Alteraciones del perfil epitranscriptómico (m6A) asociadas a mecanismos biológicos del cáncer colorrectal y obesidad.
(2023-11-24)La obesidad considerada un factor de riesgo crucial en el inicio y progresión del cáncer colorrectal, podría promover un microentorno favorable a la carcinogénesis mediado por alteraciones epitranscriptómicas, como la ... -
Association between metabolic status and the methylation level of genes involved in metabolic disorders and obesity
Castellano-Castillo, Daniel; Moreno-Indias, Isabel; Picon-Cesar, María José; Garcia-Aleman, Jorge; Macias-Gonzalez, Manuel; Tinahones-Madueño, Francisco José; Queipo-Ortuño, María Isabel; Cardona-Díaz, Fernando[et al.] (2014-08-01)
Objectives: DNA methylation is one of the epigenetic mechanims to control gene expression, and it is believed to be modulated by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain ... -
Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer
Boughanem, Hatim; Cabrera-Mulero, Amanda; Hernández Alonso, Daniel; Clemente-Postigo, María Mercedes; Casanueva, Felipe F.; Tinahones-Madueño, Francisco José; Morcillo Espina, Sonsoles; Crujeiras Martínez, Ana Belén; Macías-González, Manuel[et al.] (Springer Nature, 2020)
Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC ... -
Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study
(Wiley, 2022-03-28)Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. Accordingly, long-term obesity is involved in an increased risk of developing several metabolic ... -
New insights in the regulation of IGFPBs by PPARG2 to protect against insulin resistance in morbid obesity.
Moreno Santos, Inmaculada; Castellano-Castillo, Daniel; Cardona-Díaz, Fernando; Garrido, Lourdes; García-Fuentes, Eduardo; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (2012-06-28)
his study examines the role of PPARγ2 and IGFBPs in visceral adipose tissue of morbidly obese patients with varying insulin resistance (IR). PPARγ2 expression was lower in those with high IR, while IGFBP-2 showed protective ... -
Relación de la obesidad y la diabetes tipo 2 con los niveles plasmáticos de vitamina D y con la expresión génica del receptor de vitamina D en tejido adiposo.
Muñoz-Garach, Araceli; Clemente-Postigo, María Mercedes; Garrido López, Lourdes; Bernal-López, Rosa; Moreno-Santos, Inmaculada; Castellano-Castillo, Daniel; Fernández-García, Diego; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Elsevier, 2013-05-15)
Introducción: Se ha descrito que la deficiencia de vitamina D está asociada con la obesidad y la diabetes. Sin embargo, los re- sultados de los diferentes estudios no llegan a ser del todo conclu- yentes. Asimismo, se ha ... -
Relación de los niveles de vitamina D y la expresión de VDR en tejido adiposo con el índice de masa corporal y el perfil glucémico.
Clemente-Postigo, María Mercedes; Muñoz-Garach, Araceli; Garrido-Sánchez, Lourdes; Bernal-López, Rosa; Moreno-Santos, Inmaculada; Castellano-Castillo, Daniel; Fernández-García, Diego; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (2012)
Este estudio analizó la relación entre los niveles de vitamina D (25(OH)D3), la expresión del receptor de vitamina D (VDR) en tejido adiposo visceral, el índice de masa corporal (IMC) y el perfil glucémico en 119 sujetos ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
Clemente-Postigo, María Mercedes; Muñoz Garach, Araceli; Serrano, Marta; Garrido-Sánchez, Lourdes; Bernal-López, María Rosa; Fernandez-García, Diego; Moreno Santos, Inmaculada; Garriga, Nuria; Castellano-Castillo, Daniel; Camargo, Antonio; Fernández Real, José M; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Endocrine Society, 2015)
Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ... -
Study of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesity
(2023-12-01)Although the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and ... -
The emergent role of mitochondrial RNA modifications in metabolic alterations
(Wiley, 2022-07-25)Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial ...