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Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner, Stefania; Martini, Alessandra; Prieto, Gilberto Aleph; Dang, Cindy; Rodriguez-Ortiz, Carlos; Reyes Ruiz, Jorge Mauricio; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Andrews, Elizabeth; Phan, Jimmy; Ha, Jordan; Chang, Allissa; Levites, Yona; Cruz, Pedro; Ager, Rahasson; Medeiros, Rodrigo; Kitazawa, Masashi; Glabe, Charles; Cotman, Carl; Golde, Todd; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Springer Nature, 2019-11)Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with ...