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Listar por autor "Malim, Michael H."
Mostrando ítems 1-11 de 11
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Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
Burnap, Sean A.; Ortega-Prieto, Ana María; Jimenez-Guardeño, Jose Manuel; Ali, Hashim; Takov, Kaloyan; Fish, Matthew; Shankar-Hari, Manu; Giacca, Mauro; Malim, Michael H.; Mayr, Manuel[et al.] (Elsevier, 2023)High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key ... -
Drug repurposing based on a quantum-inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2.
Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana María; Menéndez-Moreno, Borja; Maguire, Thomas; Richardson, Adam; Díaz-Hernández, Juan Ignacio; Díez- Pérez, Javier; Zuckerman, Mark; Cordero-Deline, Carlos; Malim, Michael H.; Martínez-Núñez, Rocío Teresa[et al.] (PLOS, 2022)The COVID-19 pandemic has accelerated the need to identify new antiviral therapeutics at pace, including through drug repurposing. We employed a Quadratic Unbounded Binary Optimization (QUBO) model, to search for compounds ... -
Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
Braga, Luca; Ali, Hashim; Secco, Ilaria; Chiavacci, Elena; Neves, Guilherme; Goldhill, Daniel; Penn, Rebecca; Jimenez-Guardeño, Jose Manuel; Ortega-Prieto, Ana María; Bussani, Rossana; Cannata, Antonio; Rizzari, Giorgia; Collesi, Chiara; Scheider, Edoardo; Arosio, Daniele; Ajay M, Shah; Barclay, Wendy S; Malim, Michael H.; Burrone, Juan; Giacca, Mauro[et al.] (Springer Nature, 2021)COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar ... -
Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Jiménez-Guardeño, José Manuel; Apolonia, Luis; Betancor, Gilberto; Malim, Michael H. (Springer Nature, 2019)Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally ... -
Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice.
Skelton, Jessica Katy; Ortega-Prieto, Ana María; Kaye, Steve; Jimenez-Guardeño, Jose Manuel; Turner, Jane; Malim, Michael H.; Towers, Greg J.; Dorner, Marcus[et al.] (ASM Journals, 2019-05-15)Human immunodeficiency virus type 1 (HIV-1) infection is associated with aberrant immune activation; however, most model systems for HIV-1 have been used during established infection. Here, we utilize ultrasensitive HIV-1 ... -
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Seow, Jeffrey; Graham, Carl; Merrick, Blair; Acors, Sam; Pickering, Suzanne; Steel, Kathryn JA; Hemmings, Oliver; O'Byrne, Aoife; Kouphou, Neophytos; Galao, Rui Pedro; Betancor, Gilberto; Wilson, Harry D; Signell, Adrian W; Winstone, Helena; Kerridge, Claire; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Lista, Maria Jose; Temperton, Nigel; Snell, Luke B; Bisnauthsing, Karen; Moore, Amelia; Green, Adrian; Martinez, Lauren; Stokes, Brielle; Honey, Johanna; Izquierdo-Barras, Alba; Arbane, Gill; Patel, Amita; Ik Tan, Mark Kia; O'Connell, Lorcan; O'Hara, Geraldine; MacMahon, Eithne; Douthwaite, Sam; Nebbia, Gaia; Batra, Rahul; Martinez-Nunez, Rocio; Shankar-Hari, Manu; Edgeworth, Jonathan D; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (2020)Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10-15 d after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS-CoV-2 in the human population, it is not known how ... -
Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction
Dicks, Matthew DJ; Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Pessel-Vivares, Lucie; Apolonia, Luis; Goujon, Caroline; Malim, Michael H.[et al.] (Public Library of Science, 2018)Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced post-entry inhibitor of human immunodeficiency virus type-1 (HIV-1) infection. While the precise mechanism of viral inhibition remains unclear, MX2 is localized ... -
MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation
Betancor, Gilberto; Jimenez-Guardeño, Jose Manuel; Lynham, Steven; Antrobus, Robin; Khan, Hataf; Sobala, Andrew; Dicks, Matthew DJ; Malim, Michael H.[et al.] (Springer Nature, 2021)The antiviral cytokine interferon activates expression of interferon-stimulated genes to establish an antiviral state. Myxovirus resistance 2 (MX2, also known as MxB) is an interferon-stimulated gene that inhibits the ... -
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant
Graham, Carl; Seow, Jeffrey; Huettner, Isabella; Khan, Hataf; Kouphou, Neophytos; Acors, Sam; Winstone, Helena; Pickering, Suzanne; Galao, Rui Pedro; Dupont, Liane; Lista, Maria Jose; Jimenez-Guardeño, Jose Manuel; Laing, Adam G; Wu, Yin; Joseph, Magdalene; Muir, Luke; van Gils, Marit J; Ng, Weng M; Duyvesteyn, Helen ME; Zhao, Yuguang; Bowden, Thomas A; Shankar-Hari, Manu; Rosa, Annachiara; Cherepanov, Peter; McCoy, Laura E; Hayday, Adrian C; Neil, Stuart JD; Malim, Michael H.; Doores, Katie J[et al.] (Elsevier, 2021)Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes ... -
Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concern.
Dupont, Liane; Snell, Luke B; Graham, Carl; Seow, Jeffrey; Merrick, Blair; Lechmere, Thomas; Maguire, Thomas; Hallett, Sadie R.; Pickering, Suzanne; Charalampous, Themoula; Alcolea-Medina, Adela; Huettner, Isabella; Jimenez-Guardeño, Jose Manuel; Acors, Sam; Almeida, Nathalia; Cox, Daniel; Dickenson, Ruth; Galao, Rui Pedro; Kouphou, Neophytos; Lista, Maria Jose; Ortega-Prieto, Ana María; Wilson, Harry D; Winstone, Helena; Fairhead, Casssandra; Su, Jia Zhe; Nebbia, Gaia; Batra, Rahul; Neil, Stuart JD; Shankar-Hari, Manu; Edgeworth, Jonathan D; Malim, Michael H.; Doores, Katie J[et al.] (Nature Research, 2021)COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability and cross-neutralizing potential against SARS-CoV-2 and emerging variants of concern (VOCs). Analyses ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
Ortega-Prieto, Ana María; Boehmer, Nina; Dinc, Hanife; Betancor, Gilberto; Petrosyan, Eduard; Malim, Michael H.; Jiménez-Guardeño, José Manuel[et al.] (2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...