Listar por autor "López de San Sebastián, Javier"
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A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis.
Rodríguez-Pérez, Luis Manuel
; López-de-San-Sebastián, Javier; De-Diego-Barbado, Isabel; Smith-Fernández, José Aníbal; Roales-Buján, Ruth; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (Frontiers, 2024-02-21)
INTRODUCTION Dysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital ... -
A sequential cell therapy to recover the ependymal cells in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2022-09)
Background Germinal matrix haemorrhages and intraventricular haemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a relevant cause of morbidity and mortality in the premature neonatal population. The ... -
Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages
Rodríguez-Pérez, Luis Manuel; Ojeda-Pérez, Betsaida; López-de-San-Sebastián, Javier; García-Bonilla, María; González-García, Marcos; Fernandez-Muñoz, Beatriz; Sánchez Pernaute, Rosario; García-Martín, María L.; Domínguez-Pinos, Dolores; Cárdenas García, Casimiro; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (AHA/ASA Journals, 2024-04)
BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities ... -
Estudio de la diferenciación in vitro de progenitores ependimarios en condiciones de hidrocefalia posthemorrágica y en cotrasplante con células madre mesenquimales
(2023)El epéndimo es el epitelio que recubre las paredes del sistema ventricular cerebral, y cumple importantes funciones relacionadas con el mantenimiento y homeostasis del sistema nervioso central. Por su ubicación, el ... -
Human Mesenchymal Stem Cells and its Exosomes in Posthemorrhagic Hydrocephalus: A Focus on Edema and Ependymal Repair
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (SRHSB 2024 Annual Conference, 2023-09-04)
Background Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) often lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH is known to ... -
Multiciliated ependyma recovery through a sequential cell therapy in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús (2023)
Posthemorrhagic hydrocephalus (PHH) is a significant cause for premature children’s morbidity, mortality, and peri/postnatal neurodevelopmental impairment. PHH is mainly triggered by germinal matrix hemorrhages (GMH) and ... -
Testing exosomes as a treatment for posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2023)
Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which forms ... -
Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development.
Páez-González, Patricia; López-de-San-Sebastián, Javier; Cerón-Fúnez, Raquel; Jiménez-Lara, Antonio Jesús; Rodríguez-Pérez, Luis Manuel (Frontiers, 2023)
The epithelium covering the surfaces of the cerebral ventricular system is known as the ependyma, and is essential for maintaining the physical and functional integrity of the central nervous system. Additionally, the ...