Listar por autor "Aithal, Guruprasad P."
Mostrando ítems 1-8 de 8
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A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry.
Bjornsson, Einar S.; Stephens, Camilla; Atallah, Edmond; Robles-Díaz, María Mercedes
; Alvarez-Alvarez, Ismael; Gerbes, Alexander L; Weber, Sabine; Stirnimann, Guido; Kullak-Ublick, Gerd A; Cortez-Pinto, Helena; Grove, Jane I.; Lucena-González, María Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.[et al.] (Wiley, 2023)
Background & Aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases ... -
A revised electronic version of RUCAM for the diagnosis of DILI
Hayashi, Paul H.; Lucena-González, María Isabel; Fontana, Robert J.; Bjornsson, Einar S.; Aithal, Guruprasad P.; Barnhart, Huiman; González-Jiménez, Andrés; Yang, Qinghong; Gu, Jiezhun; Andrade-Bellido, Raúl Jesús; Hoofnagle, Jay H.[et al.] (Wiley, 2022)
Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network ... -
Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review
(Taylor & Francis, 2021-11-15)Introduction: Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas ... -
Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
Ashby, Kristin; Zhuang, Wei; González-Jiménez, Andrés; Alvarez-Alvarez, Ismael; Lucena, M. Isabel; Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; Suzuki, Ayako; Chen, Minjun[et al.] (Elsevier, 2021)
Background & aims: Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 -12% developing a chronic disease. Herein, we ... -
Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report
Andrade-Bellido, Raúl Jesús; Aithal, Guruprasad P.; De Boer, Ynto S.; Liberal, Rodrigo; Gerbes, Alexander L; Regev, Arie; Terziroli Beretta-Piccoli, Benedetta; Schramm, Christoph; Kleiner, David E.; De Martin, Eleonora; Kullak-Ublick, Gerd A; Stirnimann, Guido; Devarbhavi, Harshad; Vierling, John M.; Manns, Michael P.; Sebode, Marcial; Londoño, María Carlota; Avigan, Mark; Robles-Díaz, María Mercedes; García-Cortés, Miren; Atallah, Edmond; Heneghan, Michael; Chalasani, Naga; Trivedi, Palak J.; Hayashi, Paul H.; Taubert, Richard; Fontana, Robert J.; Weber, Sabine; Oo, Ye Htun; Zen, Yoh; Licata, Anna; Lucena-González, María Isabel; Mieli-Vergani, Giorgina; Vergani, Diego; Bjornsson, Einar S.[et al.] (Elsevier, 2023)
Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint ... -
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials
Niu, Hao; Sanabria-Cabrera, Judith Adriana; Alvarez-Alvarez, Ismael; Robles-Díaz, María Mercedes; Stankeviciute, Simona; Aithal, Guruprasad P.; Bjornsson, Einar S.; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel; Sanabria-Cabrera, Judith Adriana[et al.] (Elsevier, 2021-02)
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ... -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
Lucena-González, María Isabel; Villanueva-Paz, Marina; Alvarez-Alvarez, Ismael; Aithal, Guruprasad P.; Bjornsson, Einar S.; Cakan-Akdogan, G.; Cubero, Francisco Javier; Esteves, Freddy; Falcón-Pérez, Juan Manuel; Fromenty, B.; Garcia-Ruiz, C.; Grove, J.I.; Konu, O.; Kranendonk, M.; Kullak-Ublick, Gerd A; Miranda, J.P.; Remesal-Doblado, A.; Sancho-Bru, P.; Nelson, L.; Andrade-Bellido, Raúl Jesús; Fernandez-Checa, J.C.[et al.] (Elsevier, 2023-12-28)
In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, ... -
Therapeutic management of idiosyncratic drug‑induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review.
Niu, Hao; Atallah, Edmond; Alvarez-Alvarez, Ismael; Medina-Cáliz, Inmaculada; Aithal, Guruprasad P.; Arikan, Cigdem; Andrade-Bellido, Raúl Jesús; Lucena-González, María Isabel[et al.] (Springer Nature, 2022)
Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective: We aim to comprehensively ...