Listar por autor "Medeiros, Rodrigo"
Mostrando ítems 1-7 de 7
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Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Cadete Martini, Alessandra; Gomez-Arboledas, Angela; Forner, Stefania; Rodriguez-Ortiz, Carlos; McQuade, Amanda; Danhash, Emma; Phan, Jimmy; Javoncillo, Dominic; Ha, Jordan-Vu; Tram, Melanie; Trujillo-Estrada, Laura Isabel
; da Cunha, Celia; Ager, Rahasson; Davila, Jose Carlos; Kitazawa, Masashi; Blurton-Jones, Mathew; Gutierrez, Antonia; Baglietto-Vargas, David; Medeiros, Rodrigo; LaFerla, Frank M[et al.] (National Academy of Sciences, 2019-10)
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the ... -
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
(Elsevier, 2013-10-22)Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate ... -
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes
(Elsevier, 2014-03)Patients affected by diabetes show an increased risk of developing Alzheimer disease (AD). Similarly, patients with AD show impaired insulin function and glucose metabolism. However, the underlying molecular mechanisms ... -
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.
(Wiley, 2018-08-17)Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, ... -
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner, Stefania; Martini, Alessandra; Prieto, Gilberto Aleph; Dang, Cindy; Rodriguez-Ortiz, Carlos; Reyes Ruiz, Jorge Mauricio; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Andrews, Elizabeth; Phan, Jimmy; Ha, Jordan; Chang, Allissa; Levites, Yona; Cruz, Pedro; Ager, Rahasson; Medeiros, Rodrigo; Kitazawa, Masashi; Glabe, Charles; Cotman, Carl; Golde, Todd; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Springer Nature, 2019-11)
Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with ... -
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology
(Elsevier, 2013-09-01)Background Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here, we analyzed the effects of the ... -
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice
(Wiley, 2015-09)Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as ...